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Filtering by: Creator Lange, Sandra L. Remove constraint Creator: Lange, Sandra L. Committee Member Loesgen, Sandra Remove constraint Committee Member: Loesgen, Sandra Rights Statement In Copyright Remove constraint Rights Statement: In Copyright

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  • Bioactivity Screening and Gene Activation Strategies in Fungi

    Creator:
    Coddington, Nathan C.
    Abstract:
    Natural products from plants, bacteria, and fungi play an important role in society. Over the last 35 years, natural products and their derivatives have inspired over 60% of all FDA approved small-molecule drugs, and are among the top prescribed therapeutics.1-2 Fleming’s discovery of the fungal antibiotic penicillin started the “Golden...
    Resource Type:
    Honors College Thesis
    Full Text:
    . Abstract approved: ______________________________________________________________ Sandra Loesgen

  • Investigation of Chain Extension Approaches for the Stereoselective Reagent-Controlled Synthesis of alpha-Heteroatom Substituted Alkyl Boronic Esters

    Creator:
    Barsamian, Adam L.
    Abstract:
    Two distinct strategies were explored for the enantioselective synthesis of α-heteroatom substituted alkyl boronic esters by stereoselective reagent-controlled homologation using transient chiral carbenoid reagents CHYMX (Y = heteroatom, X = nucleofuge, M = electrofuge). In the first case, a stereospecific reagent-controlled homologation (sStReCH) approach to α-alkoxyalkylboronates using α-metalated S,O- and...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Adam L. Barsamian for the degree of Doctor of Philosophy in

  • Metabolomic Profiling of Natural Products from Two Tolypocladium Fungal Species as Part of An Evolutionary Genomics Study

    Creator:
    Dickey, Bailey J.
    Abstract:
    This thesis describes an investigation of the natural products chemistry of two fungal species of the genus Tolypocladium. Natural products are small organic molecules that are considered non-essential for cell growth and reproduction, and thus part of secondary metabolism. Chemical profiling of these secondary metabolites using a combination of high-performance...
    Resource Type:
    Masters Thesis
    Full Text:
    : ______________________________________________________ Kerry L. McPhail This thesis describes an investigation

  • Development of Carbenoid Eliminative Cross-coupling for the Stereocontrolled Synthesis of Trisubstituted Alkenyl Moieties Within Styrenes and 1,3-Dienes

    Creator:
    Tanpure, Subhash D.
    Abstract:
    Traditional approaches for the direct preparation of alkenes are unable to fully control either the stereochemical configuration of the carbon-carbon double bond or else the regiochemistry of the substituents surrounding it. The recently introduced concept of carbenoid eliminative cross-coupling (CEXC) offers a remedy to these deficiencies by providing for a...
    Resource Type:
    Dissertation
    Full Text:
    me. I wish to thank my committee members Dr. Kevin Gable, Dr. Sandra Loesgen, Dr. Christopher

  • Natural Products Discovery from Unique Microbial Habitats

    Creator:
    Gallegos, David A.
    Abstract:
    Marine natural products possess an abundance of diverse chemical scaffolds with unique biological activities. By targeting unusual or unique microbial environments within varying marine ecologies we can continue to discover novel chemistry with potentially new molecular targets. The research presented here is focused on exploring unusual chemical ecologies and the...
    Resource Type:
    Dissertation
    Full Text:
    Habitats. Abstract approved: ______________________________________________________ Kerry L

  • Establishment and dynamics of methane-oxidizing microbial communities in marine sediments

    Creator:
    Klasek, Scott A.
    Abstract:
    Marine sediments are vast sources and reservoirs of methane, a potent greenhouse gas. Most of this methane is anaerobically oxidized by archaea before it can reach the overlying ocean, though the efficiency of this process often depends on methane fluxes and mechanisms of fluid transport. Anaerobic methanotrophic archaea, or ANME,...
    Resource Type:
    Dissertation
    Full Text:
    contagious. My other committee members, Ryan Mueller, Peter Bottomley, and Sandra Loesgen, have also

  • Stereospecific Synthesis of Stereotriad Motifs and Alkenes Using Enantioenriched sp³-Hybridized Carbenoids

    Creator:
    Xun, Sun
    Abstract:
    Enantioenriched sp³-hybridized carbenoid reagents CR1R2MX (X = nucleofuge, M = electrofuge) of different types were investigated for the synthesis of polysubstituted alkyl chains by iterative stereospecific reagent-controlled homologation (StReCH) and for the stereospecific connective synthesis of alkenes by eliminative cross-coupling. In the first part, putative enantioenriched α-chloroalkyllithiums (CHRLiCl) were employed...
    Resource Type:
    Dissertation
    Full Text:
    :  “Carbenoid”  described  by  Friedman  et  al.[2]   Three  years  later,  G.  L.  Closs

  • Selective oxidation of biological matrices for subsequent peroxidase and peroxidase-based quantitative analyses

    Creator:
    Jiang, Shu
    Abstract:
    Hydrogen peroxide quantification is of broad interest due to the common use of hydrogen peroxide as an oxidizing agent in industrial processing and laboratory research. Hydrogen peroxide assays are also of general importance for biological studies aimed at understanding the role of in situ generated reactive oxygen species. In the...
    Resource Type:
    Masters Thesis
    Full Text:
    accomplished without him. I am also thankful to my thesis committee members: Dr. Sandra Loesgen, Dr

  • Progress Towards the Total Synthesis of Bazzanin K

    Creator:
    Salvo, Patrick
    Abstract:
    Molecular chirality plays a critical role in chemistry, biology, and medicine. To study and better understand conformational chirality, it is necessary to obtain structurally interesting molecules that exhibit this form of chirality. Our lab utilizes total synthesis and methodological development to obtain conformationally chiral natural products of interest. We believe...
    Resource Type:
    Masters Thesis
    Full Text:
    . 5 B. S. Moore, J. L. Chen, G. M. L. Patterson, R. E. Moore, L. S. Brinen, Y. Kato, and J. Clardy, J

  • The Role of Materials Chemistry in Designing Advanced Color Inorganic Pigments

    Creator:
    Medina, Elena A.
    Abstract:
    The results of the research presented in this work are related to synthesis and investigations of novel color inorganic pigments having various structures and shades. Inorganic pigments play a major role in contemporary life. They are used in paints, rubber, plastic, cosmetics etc. Searching for new, stable, environmentally benign and...
    Resource Type:
    Dissertation
    Full Text:
    , color characterization (L*a*b* parameters), optical (UV-VIS diffuse reflectance and near- IR (NIR