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Filtering by: Creator Corden, Malcolm E. Remove constraint Creator: Corden, Malcolm E. Committee Member Lowry, Malcolm Remove constraint Committee Member: Lowry, Malcolm

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  • Structure-function analysis of the vaccinia virus I7L proteinase

    Creator:
    Moerdyk, Megan J.
    Abstract:
    Vaccinia virus is the prototypic member of the Orthopoxvirus genus. It undergoes a complex replication process where a key step in the transition from immature virion to intracellular mature virion is the cleavage of the major core protein precursors. The product of the I7L open reading frame (ORF) is a...
    Resource Type:
    Masters Thesis
    Full Text:
    approved: ______________________________________________________________ Dennis E. Hruby

  • Rift Valley fever in African buffalo (Syncerus caffer) : basic epidemiology and the role of bovine tuberculosis coinfection

    Creator:
    Beechler, Brianna
    Abstract:
    Rift Valley fever (RVF) is a mosquito-borne zoonotic viral disease native to the African continent. Outbreaks tend to occur in the wet seasons, and can affect numerous mammalian species including African buffalo. It is debated how the virus survives the inter-epidemic period when it is not detected in mammalian populations,...
    Resource Type:
    Dissertation
    Full Text:
    Tuberculosis Coinfection Abstract approved: Anna E Jolles Rift Valley fever (RVF) is

  • Identification of intracellular trafficking signals contained within the vaccinia virus F13L protein

    Creator:
    Honeychurch, Kady M.
    Abstract:
    The F13L protein is the major envelope antigen of vaccinia virus, the prototypic member of the Orthopoxvirus genus. F13L is 372 residues in length and is essential for the formation of wrapped forms of virus. F13L contains a number of potential functional domains including a palmitylation site, a phospholipase domain...
    Resource Type:
    Dissertation
    Full Text:
    : ________________________________________________________________________ Dr. Dennis E. Hruby The F13L protein is the major envelope antigen of vaccinia virus

  • Characterizing Mycobacterium avium subspecies hominissuis (MAH) Microaggregate Induction of Innate Immunity

    Creator:
    Keefe, Bailey F.
    Abstract:
    Bacterial aggregation is a strategy employed by many pathogens to establish infection. Mycobacterium avium subsp. hominissuis (MAH) undergoes a phenotypic change, microaggregation, when exposed to the respiratory epithelium. This aggregation is an important step in the pathogenesis of the infection, laying the foundation for biofilm formation. We therefore compared how...
    Resource Type:
    Masters Thesis
    Full Text:
    : ______________________________________________________ Luiz E. Bermudez Bacterial aggregation is a strategy employed by many pathogens to

  • Wildlife Health in Managed Forests : Immunity and Infectious Diseases in Wild Rodents of Oregon

    Creator:
    Hanselmann, Rhea
    Abstract:
    With continual and worldwide human population growth, our impact on the natural environment expands and intensifies every day. We consume natural resources, burn fossil fuels, and release toxic compounds into the air, water, and earth. We build roads that fragment the landscape, construct new settlements, and develop agricultural lands in...
    Resource Type:
    Dissertation
    Full Text:
    . Abstract approved: _____________________________________ Anna E. Jolles With continual and worldwide

  • Identification of Viruses Associated with Raspberry Leaf Curl Disease

    Creator:
    Guzman Martinez, Melinda
    Abstract:
    Raspberries are an important commodity worldwide, with the United States (U.S.) leading fourth in global production in 2017. An important factor when shipping propagated Rubus across the globe is the security of clean plant material verified through pathogen detection methods which is vital in preventing disease spread. A raspberry virus...
    Resource Type:
    Masters Thesis
    Full Text:
    would like to thank my committee members Drs. Malcolm Lowry, Chris Mundt, and Jay Pscheidt, who

  • Molecular and genetic assessment of selected antiporters and methyl-accepting chemotaxis proteins in Vibrio cholerae

    Creator:
    Quinn, Matthew J.
    Abstract:
    The pathogen Vibrio cholerae uses cations as a primary currency of virulence and environmental persistence, using gradients of those cations to move, acquire nutrients, and control virulence gene expression. An understanding of the overlapping roles of bioenergetics and chemotaxis in the virulence and environmental survival of V. cholerae issues from...
    Resource Type:
    Dissertation
    Full Text:
    functionally expressed in an antiporterless E. coli strain and assayed in everted membrane vesicles, Vc-NhaP1

  • The conserved biology of herpesvirus latency : a study in cyprinid herpesvirus 3

    Creator:
    Reed, Aimee N.
    Abstract:
    Cyprinid herpesvirus 3 (CyHV-3), commonly known as koi herpesvirus (KHV), is a member of the Alloherpesviridae and is a deadly pathogen for koi and common carp, Cyprinus carpio. It causes severe gill necrosis and nephritis, dermal ulceration and hemorrhage, and mass mortality of up to 100% of affected fish. Fish...
    Resource Type:
    Dissertation
    Full Text:
    ORF6 protein in an expression vector pet6XHN transformed in E. coli. Based on an analysis using

  • Effects of Feeding OmniGen-AF® on Superovulatory Response in Donor Beef Cows

    Creator:
    Snider, Alexandria P.
    Abstract:
    One assisted reproductive tool used to propagate highly desirable genetics from elite sire and dam matings is embryo transfer. Superovulation is the first part of the overall protocol and it is a required yet costly and biologically stressful procedure in cattle embryo transfer. The process of superovulation results in high...
    Resource Type:
    Dissertation
    Full Text:
    to Dr. Malcolm Lowry, Dr. Joe Klopfenstein and Dr. Bob Mason for serving as my committee members

  • Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

    Creator:
    Rohlman, Diana
    Abstract:
    The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...
    Resource Type:
    Dissertation
    Full Text:
    . To my committee members: Dr. Malcolm Lowry, Dr. Siva Kolluri, Dr. Mark Leid and Dr. Patricia Dysart