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Filtering by: Creator Magnusson, K. Committee Member Magnusson, Kathy R. Subject Peptide antibiotics

The effect of dietary compounds on human cathelicidin antimicrobial peptide gene expression mediated through farnesoid X receptor and its potential role in gastrointestinal health

Creator:

Campbell, Yan

Abstract:

The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum microbicidal agent and modulator of both the innate and adaptive immune system. It is induced by 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) through activation of the vitamin D receptor (VDR) and primary bile salts through activation of the xenobiotic nuclear receptor farnesoid X...

Resource Type:

Dissertation

Full Text:

Karplus and Dr. Kathy Magnusson. I thank Dr. Andy Karplus for your patience in answering my numerous
Adaptive diversity and divergence at frog antimicrobial peptide loci

Creator:

Tennessen, Jacob A.

Abstract:

In this dissertation I study evolutionary patterns at genes encoding antimicrobial peptides (AMPs) in frogs. AMPs are short, amphipathic, cationic, secreted proteins that kill bacteria and other pathogens through a non-catalytic mechanism that involves binding to and disrupting the microbial cell membrane. In many animal taxa, positive selection is much...

Resource Type:

Dissertation