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Filtering by: Has journal Molecular Therapy - Nucleic Acids Remove constraint Has journal: Molecular Therapy - Nucleic Acids Committee Member Mahmud, Taifo Remove constraint Committee Member: Mahmud, Taifo Creator Fei, Xiaobo Remove constraint Creator: Fei, Xiaobo

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  • Activation, incorporation and modification of capreomycidine during viomycin biosynthesis

    Creator:
    Fei, Xiaobo
    Abstract:
    Molecular genetic and enzymological techniques have been employed to study antibiotic biosynthesis. The nonproteinogenic amino acid capreomycidine is the signature residue found in the tuberactinomycin family of antitubercular peptide antibiotics and an important element of the pharmacophore. Recombinant VioG, a single module peptide synthetase from the viomycin gene cluster cloned...
    Resource Type:
    Masters Thesis
    Full Text:
    Assembly The assembly of amino acids to form NRPs is a nucleic acid template- independent process, and