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Filtering by: Has journal Molecular Therapy - Nucleic Acids Remove constraint Has journal: Molecular Therapy - Nucleic Acids Committee Member Mahmud, Taifo Remove constraint Committee Member: Mahmud, Taifo Decade 2010-2019 Remove constraint Decade: 2010-2019

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  • Phylogeny and Evolution of Gall-Associated Plant Pathogenic Bacteria

    Creator:
    Davis, Edward W., II
    Abstract:
    Gall-associated phytopathogens have unique evolutionary histories that haveshaped both their modes of infection and genomic structures. Pathogenicity of the gall-associated plant pathogens of the Rhodococcus, Agrobacterium, and Rathayibactergenera is mediated by horizontally acquired virulence loci. The relative ease of gainand loss of the virulence loci has confounded accurate characterization of...
    Resource Type:
    Dissertation
    Full Text:
    .......................................................... 27 Nucleic acid preparations

  • Lipids of the Stratum Corneum as Predictive Biomarkers for the Development of Atopic Dermatitis in a Pediatric Population

    Creator:
    Sato, William
    Abstract:
    Atopic Dermatitis (AD) is a widespread skin disorder, affecting some 20% of the world’s population. Though the precise molecular underpinnings are still being understood, changes in lipid composition within the epidermal stratum corneum (SC) layer have been shown to be closely linked with AD. Previous studies have identified several specific...
    Resource Type:
    Honors College Thesis
    Full Text:
    , and Triglyceride Species 4.1 Epidermal free fatty acid background Free fatty acids (FFAs

  • Quantitative Analysis of Mycobacterium avium subsp. hominissuis and Mycobacterium abscessus subs. abscessus Proteome in Response to Antibiotics and During Exposure to Different Environmental Conditions

    Creator:
    Rojony, Rajoana
    Abstract:
    M. avium subsp. hominissuis (MAH) and M. abscessus subsp. abscessus (MAB) both belong to the clinically important non-tuberculous mycobacterial (NTM) group that infect immunocompromised patients with AIDS and individuals with underlining lung conditions such as bronchiectasis or cystic fibrosis. The main challenge of treating MAH and MAB patients is an...
    Resource Type:
    Masters Thesis
    Full Text:
    treatment for 18-24 month. The need for prolonged therapy for MAH and MAB treatment influences the

  • Structural Insights into Novel Sugar Phosphate Cyclases and Flavoenzymes

    Creator:
    Kean, Kelsey M.
    Abstract:
    The function of a protein is defined by its three-dimensional structure, and in understanding the three-dimensional structure of a protein, we gain an understanding of its function and mechanism. Protein structures, especially at high resolution, can provide detailed insights into many elements of enzyme function and catalysis – identifying residues...
    Resource Type:
    Dissertation
    Full Text:
    replacing a conserved aromatic amino acid to capture the productive binding mode of the nicotinamide

  • Regulation of BCL11B by post-translational modifications

    Creator:
    Liu, Xiao
    Abstract:
    Bcl11b (B-cell lymphoma/leukemia 11b), also known as Ctip2 (Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2), is a C2H2 zinc finger transcriptional regulatory protein, which is an essential protein for post-natal life in the mouse and plays crucial roles in the development, and presumably function, of several organ systems,...
    Resource Type:
    Masters Thesis
    Full Text:
    may contribute to a better understanding of the molecular and cellular basis for Bcl11b function in

  • Biologically active metabolites from marine microorganisms : methods to identify drug leads and chemical signals

    Creator:
    Vining, Oliver B.
    Abstract:
    Microbial natural products represent a massive repository of unique chemical scaffolds with corresponding diverse biological functions. However, in the past decade the development of natural products into new therapeutics has dwindled, in part due to the challenges posed by high rediscovery rates and low throughput associated with classical bioassay-guided fractionation...
    Resource Type:
    Dissertation
    Full Text:
    synthesized the 2-amino-3-octanoic acid standards used to determine the absolute configuration of

  • Deciphering the Function of New Gonorrhea Vaccine Candidates in Cell Envelope Homeostasis

    Creator:
    Baarda, Benjamin I.
    Abstract:
    Neisseria gonorrhoeae is the sexually transmitted pathogen responsible for millions of cases of gonorrhea worldwide each year. Rapidly-spreading antibiotic resistance is diminishing the ability to effectively treat a disease with significant consequences to female and male reproductive health, as well as to neonatal well-being. A protective vaccine has the potential...
    Resource Type:
    Dissertation
    Full Text:
    3-1. Amino acid identity of MlaA homologs. .............................................. 67 Table

  • Ruminal Biodegradation of Heterocyclic Toxic Compounds

    Creator:
    Tanaree, Dan D.
    Abstract:
    Cyclic nitramines are a class of compounds that include most of the commonly used explosives today. These are among the most common toxicants released into the environment as a result of human activity, generated on military ranges, battlefields, and production sites. Of these, hexahydro-1,3,5-trinitro-1,3,5- triazine (RDX) is of particular interest,...
    Resource Type:
    Dissertation
    Full Text:
    ..................................................................... 22 1.9 Molecular Techniques and High Throughput Sequencing.......................... 22

  • Investigation of unique marine environments for microbial natural products

    Creator:
    Thornburg, Christopher C.
    Abstract:
    Metagenomics has revealed that the marine microbial biosphere is immensely more diverse than originally considered, and is an almost untapped reservoir for the potential discovery of microbial natural products. Despite numerous advances in culturing, biosynthetic engineering and genomic-based screening efforts to uncover much of this diversity in relatively accessible environments,...
    Resource Type:
    Dissertation
    Full Text:
    , ..................cytotoxicity data, molecular target or mechanism of action is listed. 8 Figure 2.1. Phylogenetic relationship

  • Quorum sensing gene regulation in Pseudomonas aeruginosa

    Creator:
    Gupta, Rashmi
    Abstract:
    Pseudomonas aeruginosa is an opportunistic human pathogen that infects immunocompromised individuals such as those suffering from burns or the genetic disorder cystic fibrosis. This organism utilizes a cell-cell communication mechanism known as quorum sensing (QS) to coordinate virulence gene expression and biofilm formation. It has three interconnected QS systems, namely...
    Resource Type:
    Dissertation
    Full Text:
    quorum sensing (QS). Thus, understanding the molecular basis and evolution of QS signaling is central