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Filtering by: Has journal Molecular Therapy - Nucleic Acids Committee Member Mahmud, Taifo Degree Field Biochemistry and Biophysics

Lipids of the Stratum Corneum as Predictive Biomarkers for the Development of Atopic Dermatitis in a Pediatric Population

Creator:

Sato, William

Abstract:

Atopic Dermatitis (AD) is a widespread skin disorder, affecting some 20% of the world’s population. Though the precise molecular underpinnings are still being understood, changes in lipid composition within the epidermal stratum corneum (SC) layer have been shown to be closely linked with AD. Previous studies have identified several specific...

Resource Type:

Honors College Thesis

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, and Triglyceride Species 4.1 Epidermal free fatty acid background Free fatty acids (FFAs
Employing Genetic Code Expansion Tools to Elucidate Disease Mechanisms and Generate New Therapeutics

Creator:

Van Fossen, Elise M.

Abstract:

In biology, function and disease are closely intertwined, requiring the coordination of hundreds of intricate chemical reactions. Interdisciplinary cooperation between chemical and biological approaches is necessary to decipher the chemical links between physiological and pathological conditions. In this arena, the precision tools made possible with chemical biology can manipulate and...

Resource Type:

Dissertation

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in areas where exquisite molecular precision and definition is required. GCE is a dual force in
Structural Insights into Novel Sugar Phosphate Cyclases and Flavoenzymes

Creator:

Kean, Kelsey M.

Abstract:

The function of a protein is defined by its three-dimensional structure, and in understanding the three-dimensional structure of a protein, we gain an understanding of its function and mechanism. Protein structures, especially at high resolution, can provide detailed insights into many elements of enzyme function and catalysis – identifying residues...

Resource Type:

Dissertation

Full Text:

replacing a conserved aromatic amino acid to capture the productive binding mode of the nicotinamide

ScholarsArchive@OSU

Lipids of the Stratum Corneum as Predictive Biomarkers for the Development of Atopic Dermatitis in a Pediatric Population

Employing Genetic Code Expansion Tools to Elucidate Disease Mechanisms and Generate New Therapeutics

Structural Insights into Novel Sugar Phosphate Cyclases and Flavoenzymes

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