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Filtering by: Has journal Molecular Therapy - Nucleic Acids Remove constraint Has journal: Molecular Therapy - Nucleic Acids Committee Member Mahmud, Taifo Remove constraint Committee Member: Mahmud, Taifo Degree Level Master's Remove constraint Degree Level: Master's

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  • Activation, incorporation and modification of capreomycidine during viomycin biosynthesis

    Creator:
    Fei, Xiaobo
    Abstract:
    Molecular genetic and enzymological techniques have been employed to study antibiotic biosynthesis. The nonproteinogenic amino acid capreomycidine is the signature residue found in the tuberactinomycin family of antitubercular peptide antibiotics and an important element of the pharmacophore. Recombinant VioG, a single module peptide synthetase from the viomycin gene cluster cloned...
    Resource Type:
    Masters Thesis
    Full Text:
    Assembly The assembly of amino acids to form NRPs is a nucleic acid template- independent process, and

  • Quantitative Analysis of Mycobacterium avium subsp. hominissuis and Mycobacterium abscessus subs. abscessus Proteome in Response to Antibiotics and During Exposure to Different Environmental Conditions

    Creator:
    Rojony, Rajoana
    Abstract:
    M. avium subsp. hominissuis (MAH) and M. abscessus subsp. abscessus (MAB) both belong to the clinically important non-tuberculous mycobacterial (NTM) group that infect immunocompromised patients with AIDS and individuals with underlining lung conditions such as bronchiectasis or cystic fibrosis. The main challenge of treating MAH and MAB patients is an...
    Resource Type:
    Masters Thesis
    Full Text:
    treatment for 18-24 month. The need for prolonged therapy for MAH and MAB treatment influences the

  • Regulation of BCL11B by post-translational modifications

    Creator:
    Liu, Xiao
    Abstract:
    Bcl11b (B-cell lymphoma/leukemia 11b), also known as Ctip2 (Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2), is a C2H2 zinc finger transcriptional regulatory protein, which is an essential protein for post-natal life in the mouse and plays crucial roles in the development, and presumably function, of several organ systems,...
    Resource Type:
    Masters Thesis
    Full Text:
    may contribute to a better understanding of the molecular and cellular basis for Bcl11b function in

  • Biosynthetic studies of fungal diterpene antibiotics

    Creator:
    Yao, Qingmei
    Abstract:
    The isoprenoid pathway is one of the major biosynthetic pathways of secondary metabolites. Isoprenoids with a C₂₀ skeleton are known as diterpenoids and are derived from the common precursor, geranylgeranyl diphosphate (GGPP). This dissertation describes approaches to discover the diterpene synthase enzymes which provide the backbone structures for pleuromutilin and...
    Resource Type:
    Masters Thesis
    Full Text:
    and nucleic acids that are essential for living organisms. Secondary metabolites are substances that

  • Gadusol Production in Saccharomyces cerevisiae

    Creator:
    Holzwarth, Garrett
    Abstract:
    Gadusol is a UV-B-absorbent compound found in fish and other marine organisms where it is presumed to play a role as a sunscreen and antioxidant. In light of commercial potential as a replacement for problematic synthetic sunscreens, a process to produce recombinant gadusol in the yeast Saccharomcyces cerevisiae was investigated....
    Resource Type:
    Masters Thesis
    Full Text:
    ’- azinobis(3- ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS). In the ORAC assay, gadusol

  • Inactivation Strategy for Clostridium perfringens Spores Adhered onto Stainless Steel Surfaces

    Creator:
    Alzubeidi, Yasmeen S.
    Abstract:
    Clostridium perfringens is a spore-forming pathogenic bacterium that causes a variety of diseases in human and animals. C. perfringens type A isolates produce enterotoxin (CPE) causing food poisoning (FP) and non-food-borne (NFB) gastrointestinal (GI) diseases including antibiotic-associated diarrhea and sporadic diarrhea. C. perfringens type A food poisoning currently ranks as...
    Resource Type:
    Masters Thesis
    Full Text:
    Sodium hydroxide (NaOH)……………………………….. 25 2.9.2 Nitric acid (HNO3)………………………………………... 26