Index Catalog // ScholarsArchive@OSU

Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics

Creator:: Blanchard, David, L.
Abstract:: L-pipecolic acid (L-PA) is the higher homolog of proline. It occurs naturally in many organisms, including primates, as an intermediate in lysine degradation. The pathway by which lysine is converted into L-pipecolic acid employs the enzyme Lpipecolate oxidase (L-PO), and appears to be tissue specific to the central nervous system...
Resource Type:: Dissertation
Full Text:: 18, 2008. Title: Advanced Studies on Cyclic Amino Acids Involved in GABAergic Neurotransmission

Ascorbylation- the biological relevance of covalently bound ascorbic acid

Creator:: Kesinger, Nicholas G.
Abstract:: Ascorbic acid, or vitamin C, is well known as a co-factor for proline-hydroxylase and as an anti-oxidant. However, it is also capable of forming covalent bonds, particularly in the role of a nucleophile, henceforth termed 'ascorbylation'. The ascorbylation of electrophiles can occur under physiological conditions. Furthermore, there are a number...
Resource Type:: Dissertation
Full Text:: . Title: Ascorbylation- the Biological Relevance of Covalently Bound Ascorbic Acid. Abstract

Phylogeny and Evolution of Gall-Associated Plant Pathogenic Bacteria

Creator:: Davis, Edward W., II
Abstract:: Gall-associated phytopathogens have unique evolutionary histories that haveshaped both their modes of infection and genomic structures. Pathogenicity of the gall-associated plant pathogens of the Rhodococcus, Agrobacterium, and Rathayibactergenera is mediated by horizontally acquired virulence loci. The relative ease of gainand loss of the virulence loci has confounded accurate characterization of...
Resource Type:: Dissertation
Full Text:: .......................................................... 27 Nucleic acid preparations

Deciphering the molecular mechanisms of the transcriptional regulation mediated by orphan nuclear receptor COUP-TFI and C2H2 zinc finger protein Ctip2

Creator:: Zhang, Lingjuan
Abstract:: COUP-TFI, an orphan nuclear receptor of the steroid/thyroid hormone receptor superfamily, plays important roles in homeostasis and the CNS development, including differentiation, patterning, axonal projection, cell migration, cortical arealization and the temporal specification of neural stem cells. A number of COUP-interacting proteins have been described previously, and the majority of...
Resource Type:: Dissertation
Full Text:: presented on June 5, 2009 . Title: Deciphering the Molecular Mechanisms of the Transcriptional

Identification and quantitation of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites in vivo as biomarkers of oxidative stress

Creator:: Kuiper, Heather C.
Abstract:: Oxidative stress occurs when the balance between reactive oxygen species and antioxidant defense mechanisms in the body becomes tipped heavily in favor of the reactive oxygen species. Reactive oxygen species can be present in excess due to elevated O2 levels, radiation, infection, smoking, or even excessive exercise. It is also...
Resource Type:: Dissertation
Full Text:: -193 19. Lovell, M. A., and Markesbery, W. R. (2007) Nucleic Acids Res. 35(22), 7497- 7504 20. Doorn

Lipids of the Stratum Corneum as Predictive Biomarkers for the Development of Atopic Dermatitis in a Pediatric Population

Creator:: Sato, William
Abstract:: Atopic Dermatitis (AD) is a widespread skin disorder, affecting some 20% of the world’s population. Though the precise molecular underpinnings are still being understood, changes in lipid composition within the epidermal stratum corneum (SC) layer have been shown to be closely linked with AD. Previous studies have identified several specific...
Resource Type:: Honors College Thesis
Full Text:: , and Triglyceride Species 4.1 Epidermal free fatty acid background Free fatty acids (FFAs

Employing Genetic Code Expansion Tools to Elucidate Disease Mechanisms and Generate New Therapeutics

Creator:: Van Fossen, Elise M.
Abstract:: In biology, function and disease are closely intertwined, requiring the coordination of hundreds of intricate chemical reactions. Interdisciplinary cooperation between chemical and biological approaches is necessary to decipher the chemical links between physiological and pathological conditions. In this arena, the precision tools made possible with chemical biology can manipulate and...
Resource Type:: Dissertation
Full Text:: in areas where exquisite molecular precision and definition is required. GCE is a dual force in

Quantitative Analysis of Mycobacterium avium subsp. hominissuis and Mycobacterium abscessus subs. abscessus Proteome in Response to Antibiotics and During Exposure to Different Environmental Conditions

Creator:: Rojony, Rajoana
Abstract:: M. avium subsp. hominissuis (MAH) and M. abscessus subsp. abscessus (MAB) both belong to the clinically important non-tuberculous mycobacterial (NTM) group that infect immunocompromised patients with AIDS and individuals with underlining lung conditions such as bronchiectasis or cystic fibrosis. The main challenge of treating MAH and MAB patients is an...
Resource Type:: Masters Thesis
Full Text:: treatment for 18-24 month. The need for prolonged therapy for MAH and MAB treatment influences the

Studies on 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Synechocystis sp. PCC6803 : characterization of mutants and inhibitors

Creator:: Fernandes, Roberta P. M.
Abstract:: In recent years, the methyl erythritol phosphate (MEP) pathway to isoprenoids has been the subject of intensive research. The interest is because isoprenoids have important roles in many cellular processes essential for the survival of several pathogenic organisms, making the inhibition of this pathway an attractive target for the drug...
Resource Type:: Dissertation
Full Text:: acids residues shown to be in the DXR active site in the available E. coli crystal structures were also

Structural Insights into Novel Sugar Phosphate Cyclases and Flavoenzymes

Creator:: Kean, Kelsey M.
Abstract:: The function of a protein is defined by its three-dimensional structure, and in understanding the three-dimensional structure of a protein, we gain an understanding of its function and mechanism. Protein structures, especially at high resolution, can provide detailed insights into many elements of enzyme function and catalysis – identifying residues...
Resource Type:: Dissertation
Full Text:: replacing a conserved aromatic amino acid to capture the productive binding mode of the nicotinamide

ScholarsArchive@OSU

Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics

Ascorbylation- the biological relevance of covalently bound ascorbic acid

Phylogeny and Evolution of Gall-Associated Plant Pathogenic Bacteria

Deciphering the molecular mechanisms of the transcriptional regulation mediated by orphan nuclear receptor COUP-TFI and C2H2 zinc finger protein Ctip2

Identification and quantitation of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites in vivo as biomarkers of oxidative stress

Lipids of the Stratum Corneum as Predictive Biomarkers for the Development of Atopic Dermatitis in a Pediatric Population

Employing Genetic Code Expansion Tools to Elucidate Disease Mechanisms and Generate New Therapeutics

Quantitative Analysis of Mycobacterium avium subsp. hominissuis and Mycobacterium abscessus subs. abscessus Proteome in Response to Antibiotics and During Exposure to Different Environmental Conditions

Studies on 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Synechocystis sp. PCC6803 : characterization of mutants and inhibitors

Structural Insights into Novel Sugar Phosphate Cyclases and Flavoenzymes

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