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Filtering by: Has journal Molecular Therapy - Nucleic Acids Remove constraint Has journal: Molecular Therapy - Nucleic Acids Committee Member Mahmud, Taifo Remove constraint Committee Member: Mahmud, Taifo Subject Biosynthesis Remove constraint Subject: Biosynthesis

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  • Activation, incorporation and modification of capreomycidine during viomycin biosynthesis

    Creator:
    Fei, Xiaobo
    Abstract:
    Molecular genetic and enzymological techniques have been employed to study antibiotic biosynthesis. The nonproteinogenic amino acid capreomycidine is the signature residue found in the tuberactinomycin family of antitubercular peptide antibiotics and an important element of the pharmacophore. Recombinant VioG, a single module peptide synthetase from the viomycin gene cluster cloned...
    Resource Type:
    Masters Thesis
    Full Text:
    Assembly The assembly of amino acids to form NRPs is a nucleic acid template- independent process, and

  • Biosynthetic studies of fungal diterpene antibiotics

    Creator:
    Yao, Qingmei
    Abstract:
    The isoprenoid pathway is one of the major biosynthetic pathways of secondary metabolites. Isoprenoids with a C₂₀ skeleton are known as diterpenoids and are derived from the common precursor, geranylgeranyl diphosphate (GGPP). This dissertation describes approaches to discover the diterpene synthase enzymes which provide the backbone structures for pleuromutilin and...
    Resource Type:
    Masters Thesis
    Full Text:
    and nucleic acids that are essential for living organisms. Secondary metabolites are substances that