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Filtering by: Creator Dumas, Philip Conrad Committee Member Mahmud, Taifo

Studies on 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Synechocystis sp. PCC6803 : characterization of mutants and inhibitors

Creator:

Fernandes, Roberta P. M.

Abstract:

In recent years, the methyl erythritol phosphate (MEP) pathway to isoprenoids has been the subject of intensive research. The interest is because isoprenoids have important roles in many cellular processes essential for the survival of several pathogenic organisms, making the inhibition of this pathway an attractive target for the drug...

Resource Type:

Dissertation
Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics

Creator:

Blanchard, David, L.

Abstract:

L-pipecolic acid (L-PA) is the higher homolog of proline. It occurs naturally in many organisms, including primates, as an intermediate in lysine degradation. The pathway by which lysine is converted into L-pipecolic acid employs the enzyme Lpipecolate oxidase (L-PO), and appears to be tissue specific to the central nervous system...

Resource Type:

Dissertation

Full Text:

: Dr. Philip Proteau, Dr. Taifo Mahmud, Dr. Xihou Yin, and Dr. Thomas Savage for their proofreading
Functional analysis of the biosynthetic gene cluster of the antitumor agent cetoniacytone A

Creator:

Wu, Xiumei

Abstract:

A gene cluster responsible for the biosynthesis of the antitumor agent cetoniacytone A was identified in Actinomyces sp. strain Lu 9419, an endosymbiotic bacteria isolated from the intestines of the rose chafer beetle. The nucleotide sequence analysis of the 26 Kb DNA region revealed the presence of 17 complete ORFs,...

Resource Type:

Dissertation

Full Text:

Dr. Philip J. Proteau’s lab and Dr. Kerry L. McPhail’s lab for their help on my research work