Index Catalog // ScholarsArchive@OSU

Determination of ethyl glucuronide and ethyl sulfate as human biomarkers of alcohol exposure in urine by liquid chromatography/electrospray tandem mass spectrometry with large volume injection

Creator:: Hu, Yan
Abstract:: This research was undertaken to develop a sensitive, selective, and rapid analytical method to measure ethyl glucuronide (EtG) and ethyl sulfate (EtS) in urine as urinary biomarkers of alcohol exposure. Large-volume injection (LVI) coupled with liquid chromatography / electrospray tandem mass spectrometry was used to eliminate the need for either...
Resource Type:: Masters Thesis
Full Text:: . Claudia Maier, and Dr. Fredrick Prahl, for their advice on the dissertation content throughout the

A Graph Grammar Representation of Metal-Organic Frameworks for Computational Synthesis and Exploration

Creator:: Geringer, Mark K.
Abstract:: In this work, metal-organic frameworks (MOFs) are computationally represented, generated, and evaluated. The organic linker molecules are represented as graphs and use graph grammars where the atoms are represented by nodes and the bonds are represented by arcs. The grammar rules that dictate the graph generation process work on the...
Resource Type:: Masters Thesis

Development of materials and devices for separation of polyamido[a]mine dendrimers

Creator:: Tennico, Yolanda H.
Abstract:: Over the last decade, the use of highly branched macromolecules, called dendrimers, is emerging. Polyamidoamine (PAMAM) dendrimers, in particular, have attracted high interest due to their unique properties, such as well-defined size, shape, and solubility in water. Our group, as part of an interdisciplinary team, is currently working on developing...
Resource Type:: Masters Thesis

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

Creator:: Han, Bingnan
Abstract:: This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of eighteen new secondary metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D NMR data, respectively. Preliminary bioassays of the crude...
Resource Type:: Dissertation
Full Text:: . George Constantine, Dr. Michael Schimerlik, and Dr. Claudia Maier for their support and academic

Monolithic sorbents for microscale separations

Creator:: Doneanu, Angela
Abstract:: Over the last decade, the miniaturization of analytical systems has become an increasingly important and interesting research area. Miniaturized systems offer many advantages, including reduced reagent and sample consumption, shorter analysis times, portability and disposability. This dissertation describes novel approaches in this direction, focusing on two areas: the miniaturization of...
Resource Type:: Dissertation
Full Text:: Ingle, Dr. Michael Lerner, Dr. Claudia Maier and Dr. Gregory Rorrer for offering the academic guidance

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Creator:: Larsen, Christine A.
Abstract:: Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
Resource Type:: Dissertation
Full Text:: . David Williams and Dr. Claudia Maier. Thank you for all of your advice and suggestions. You played

Fabrication and application of polymer based microfluidic devices

Creator:: Koesdjojo, Myra T.
Abstract:: The concept of reducing laboratory operations in scale such that they fit on a microfluidic chip has been met with great enthusiasm. Lab-on-a-chip devices promise to be cost effective to operate due to reduced reagent consumption, have the potential to offer shorter analysis times due to their short path lengths,...
Resource Type:: Dissertation
Full Text:: to Dr. Chih-hung Chang, Dr. Claudia Maier, Dr. David Hackleman, and Dr. Michael Penner, for their

Analytical method development for the identification, detection, and quantification of emerging environmental contaminants in complex matrices

Creator:: Place, Benjamin J.
Abstract:: The development of analytical methods for emerging contaminants creates many unique challenges for analytical chemists. By their nature, emerging contaminants have inherent data gaps related to their environmental occurrence, fate, and impact. This dissertation is a compilation of three studies related to method development for the structural identification of emerging...
Resource Type:: Dissertation
Full Text:: . In addition, I would like to recognize my graduate committee: Dr. Stacey Harper, Dr. Claudia

Poly- and perfluorinated alkyl substance release from landfills and landfill model reactors

Creator:: Allred, Brent McKay
Abstract:: Research and public concern of poly and perfluoroalkyl substances (PFASs) as environmental contaminants has increased significantly due to the increasing number of reports of their detection in humans and wildlife. PFASs have a number of commercial applications including surfactants, coatings, polymers, and levelers, which are used on consumer products like...
Resource Type:: Dissertation
Full Text:: , Dr. Claudia Maier, and Dr. Joseph McGuire. ix CONTRIBUTION OF AUTHORS

Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation

Creator:: Zhang, Yong
Abstract:: Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled signaling pathways. Prior research suggested that some isoforms of PLC-β may exist and function as dimers, but little is known about dimerization of PLC-β. Data from coimmunoprecipitation assays of differentially-tagged PLC-β constructs and sizeexclusion chromatography of native PLC-β support homodimerization...
Resource Type:: Dissertation
Full Text:: . Paul Murtaugh, Dr. Claudia Maier and Dr. Lan Xue for their invaluable support and feedback during

ScholarsArchive@OSU

Determination of ethyl glucuronide and ethyl sulfate as human biomarkers of alcohol exposure in urine by liquid chromatography/electrospray tandem mass spectrometry with large volume injection

A Graph Grammar Representation of Metal-Organic Frameworks for Computational Synthesis and Exploration

Development of materials and devices for separation of polyamido[a]mine dendrimers

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

Monolithic sorbents for microscale separations

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Fabrication and application of polymer based microfluidic devices

Analytical method development for the identification, detection, and quantification of emerging environmental contaminants in complex matrices

Poly- and perfluorinated alkyl substance release from landfills and landfill model reactors

Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation

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