Index Catalog // ScholarsArchive@OSU

Purification of cyclotron-produced 89Zr for its use in diagnostic radiopharmaceutical labeling

Creator:: Knaus, Clinton W.
Abstract:: Production of 89Zr serves as a crucial preliminary step for exploring Zr-chelates, determining their stability constants, and advancing radiolabeling methodologies for monoclonal antibody based theranostics. 89Zr is typically produced by the irradiation of natural yttrium targets, a process extensively documented in scientific literature. Two primary methods are employed: the 89Y(p,n)89Zr...
Resource Type:: Capstone Project

A Graph Grammar Representation of Metal-Organic Frameworks for Computational Synthesis and Exploration

Creator:: Geringer, Mark K.
Abstract:: In this work, metal-organic frameworks (MOFs) are computationally represented, generated, and evaluated. The organic linker molecules are represented as graphs and use graph grammars where the atoms are represented by nodes and the bonds are represented by arcs. The grammar rules that dictate the graph generation process work on the...
Resource Type:: Masters Thesis

Determination of ethyl glucuronide and ethyl sulfate as human biomarkers of alcohol exposure in urine by liquid chromatography/electrospray tandem mass spectrometry with large volume injection

Creator:: Hu, Yan
Abstract:: This research was undertaken to develop a sensitive, selective, and rapid analytical method to measure ethyl glucuronide (EtG) and ethyl sulfate (EtS) in urine as urinary biomarkers of alcohol exposure. Large-volume injection (LVI) coupled with liquid chromatography / electrospray tandem mass spectrometry was used to eliminate the need for either...
Resource Type:: Masters Thesis
Full Text:: . Claudia Maier, and Dr. Fredrick Prahl, for their advice on the dissertation content throughout the

Development of materials and devices for separation of polyamido[a]mine dendrimers

Creator:: Tennico, Yolanda H.
Abstract:: Over the last decade, the use of highly branched macromolecules, called dendrimers, is emerging. Polyamidoamine (PAMAM) dendrimers, in particular, have attracted high interest due to their unique properties, such as well-defined size, shape, and solubility in water. Our group, as part of an interdisciplinary team, is currently working on developing...
Resource Type:: Masters Thesis

Specificity, Allostery, and Multivalency in Binding to the Hub Protein LC8

Creator:: Estelle, Aidan B.
Abstract:: Interactions between proteins are essential to life, driving and regulating a majority of processes within all living cells. Study of protein-protein interactions reveals that some proteins act as hubs within networks of interactions, binding to many partner proteins. These hubs therefore are of particular importance to understanding protein function, interwoven...
Resource Type:: Dissertation
Full Text:: our countless conversations about my work over the years. Thank you, Claudia, for donating your time

Polycyclic Aromatic Hydrocarbons in Atmospheric Fine Particulate Matter: Beyond the Priority Pollutant List

Creator:: Kramer, Amber L.
Abstract:: Atmospheric fine particulate matter (PM2.5) has been linked to the death of 7 million people per year around the planet. The organic portion of PM2.5 is responsible for increases in oxidative stress, inflammation, mutation and carcinogenesis. Anthropogenic activity releases more organic material into the atmosphere, and has increased the amount...
Resource Type:: Dissertation
Full Text:: , Claudia Meier, Mark Dolan, Alla Zelenyuk, and Stephen Giovannoni for their patience and guidance through

Drug Discovery from Diverse Bacteria – Bioactivity-guided Isolation of Known and New Metabolites

Creator:: Zhu, Chenxi
Abstract:: Exploring bioactive natural products has contributed largely to clinically approved drugs we have been using over the last 100 years. Especially among the anti-infective drugs, around 70% of currently used antibiotics were discovered or derived from microbial secondary metabolites, among them compounds like vancomycin, chloramphenicol, and erythromycin. Facing the unavoidable...
Resource Type:: Dissertation

Properties of Large Superfluid Helium Droplets

Creator:: Alghamdi, Maha
Abstract:: In this dissertation, I describe the experimental investigation of large superfluid helium droplets. The goal and direction of this thesis is to facilitate the use of these droplets as part of our project ss-EDI. The overall scheme of ss-EDI is to dope proteins inside helium droplets and collect a diffraction...
Resource Type:: Dissertation

Classifying polycyclic aromatic hydrocarbon bioactivities using phenotypic screening and transcriptomics in the developmental zebrafish model

Creator:: Geier, Mitra Celestine
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants that occur in complex mixtures. These environmental mixtures can consist of both parent PAHs and their derivatives. Several parent PAHs are known or suspected mutagens and/or carcinogens, and a handful of PAH derivatives are known to be more potent mutagens and/or carcinogens...
Resource Type:: Dissertation
Full Text:: . William Stubblefield, Dr. Molly Kile, and Dr. Claudia Maier for their guidance and support. I would

Transcriptional networks controlled by the fatty acid regulators FAR-1 and FAR-2

Creator:: Bredeweg, Erin L.
Abstract:: Fungi are capable of growth on a wide variety of carbon sources, both living and dead. They can produce an arsenal of enzymes and transporters for harvesting sugars, polysaccharides, amino acids, lipids and micronutrients from their environments [1]. Within the nucleus of a cell, transcription factors (TF) control whether genes...
Resource Type:: Dissertation
Full Text:: ! Fowler,!Dr.!Claudia!Maier,!and!Dr.!Christine!Kelly!for!their!time!and!input!during!the! process!of

ScholarsArchive@OSU

Purification of cyclotron-produced 89Zr for its use in diagnostic radiopharmaceutical labeling

A Graph Grammar Representation of Metal-Organic Frameworks for Computational Synthesis and Exploration

Determination of ethyl glucuronide and ethyl sulfate as human biomarkers of alcohol exposure in urine by liquid chromatography/electrospray tandem mass spectrometry with large volume injection

Development of materials and devices for separation of polyamido[a]mine dendrimers

Specificity, Allostery, and Multivalency in Binding to the Hub Protein LC8

Polycyclic Aromatic Hydrocarbons in Atmospheric Fine Particulate Matter: Beyond the Priority Pollutant List

Drug Discovery from Diverse Bacteria – Bioactivity-guided Isolation of Known and New Metabolites

Properties of Large Superfluid Helium Droplets

Classifying polycyclic aromatic hydrocarbon bioactivities using phenotypic screening and transcriptomics in the developmental zebrafish model

Transcriptional networks controlled by the fatty acid regulators FAR-1 and FAR-2

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