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Filtering by: Committee Member Cebra, Christopher K. Remove constraint Committee Member: Cebra, Christopher K. Committee Member Mathews, Christopher K. Remove constraint Committee Member: Mathews, Christopher K. Degree Field Genetics Remove constraint Degree Field: Genetics

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  • Phenotypic analysis of human MLH1 variants for DNA mismatch repair

    Creator:
    Hippchen, Karen Jean
    Abstract:
    DNA mismatch repair (MMR) is an evolutionarily conserved process used by cells to decrease mutation rates, thereby increasing genetic stability and reducing cancer risk. Germline mutations in the MMR gene MLH1 have been identified in Lynch Syndrome patients, and in many cases are suspected but not confirmed as causative for...
    Resource Type:
    Masters Thesis
    Full Text:
    -linear regression lines fit to the equation [Y = 100 x (e-kx)], where k = rate of decay. Dashed line