The gm/ID-based design of analog integrated circuits introduced in 1996 employs an empirical transistor sizing methodology using SPICE-generated lookup tables that enables good agreement between simulations and specifications. This thesis introduces a new SPICE lookup table that extends the gm/ID approach to the Miller pole-splitting frequency compensation of the classical...
Clean technologies can address multiple challenges associated with climate change, environmental protection, and human health. However, the impact desired by introduction of such technologies is achievable only if new options effectively replace inefficient, conventional practices. This ‘design for adoption’ requires understanding of user motivations, associated beliefs, context of use, and...
We demonstrated a low-cost and high-sensitivity DNA detection method using quantum dot-fullerene based molecular beacons (MBs) and magnetic nanoparticles. The MB tethered magnetic nanoparticles can be well dispersed in analytes for efficient DNA capture and concentrated by an external magnetic field for enhanced fluorescence signal detection. The detection requires only...
We explored an optofluidic sensing mechanism from inkjet-printed droplets on diatom biosilica using surface-enhanced Raman scattering (SERS). Our study revealed a new biosensing strategy that combines the microscopic fluidic flow induced by the droplet evaporation and the photonic crystal effects of diatom frustules, which can provide an ultra-sensitive, cost-effective biosensing...
Phenylketonuria (PKU) is a genetic inborn metabolic disorder which inhibits the functional production of the enzyme phenylalanine hydroxylase (PAH). It currently affects one in 15,000 Americans and is the most common amino acid metabolism error found in newborns. Individuals affected with PKU are incapable of metabolizing the amino acid, phenylalanine...