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Filtering by: Creator Chen, Tsu-fang Committee Member McIntyre, David Committee Member Blakemore, Paul

Gene Activation Strategies in Filamentous Fungi for Natural Products Discovery

Creator:

Adpressa, Donovon A.

Abstract:

Fungi have long been a prolific source of clinically approved drugs. The antibiotic penicillin, the cholesterol lowering statins, and the immunosuppressant cyclosporine have changed the treatment of human diseases in the last century. Recently, genome analysis of filamentous fungi has revealed that the biosynthetic potential for natural product expression is...

Resource Type:

Dissertation
Part I: Synthesis and evaluation of synosutine as an inhibitor of serotonin, norepinephrine, and dopamine transporters Part II: Asymmetric approach to the tetracyclic core of neomangicol A

Creator:

Juniku, Rajan B.

Abstract:

Part I: Racemic and asymmetric syntheses of a new substance with prospective antidepressant properties were achieved. In vitro assays with synthetic racemates (±)-25 and (±)-26 suggested that the former is a relatively selective inhibitor of serotonin transporter whereas the latter is a more balanced inhibitor of both serotonin and norepinephrine...

Resource Type:

Dissertation

Full Text:

.; Vickers, T.; Grey, J.; Foster, A. C.; Chen, Ch. Bioorg. Med. Chem. Lett. 2008, 18, 3328. 11