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Filtering by: Creator Chen, Tsu-fang Committee Member McIntyre, David Subject Antidepressants -- Synthesis

Part I: Synthesis and evaluation of synosutine as an inhibitor of serotonin, norepinephrine, and dopamine transporters Part II: Asymmetric approach to the tetracyclic core of neomangicol A

Creator:

Juniku, Rajan B.

Abstract:

Part I: Racemic and asymmetric syntheses of a new substance with prospective antidepressant properties were achieved. In vitro assays with synthetic racemates (±)-25 and (±)-26 suggested that the former is a relatively selective inhibitor of serotonin transporter whereas the latter is a more balanced inhibitor of both serotonin and norepinephrine...

Resource Type:

Dissertation

Full Text:

.; Vickers, T.; Grey, J.; Foster, A. C.; Chen, Ch. Bioorg. Med. Chem. Lett. 2008, 18, 3328. 11