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Filtering by: Creator Vial, John Nicholas Remove constraint Creator: Vial, John Nicholas Committee Member McIntyre, David Remove constraint Committee Member: McIntyre, David

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  • Multicellular monolayer’s self-organization under external stimuli

    Creator:
    Li, Guanyu
    Abstract:
    Cell signaling under external stimulation is a critical mechanism that governs many biological processes such as cell proliferation, cell migration, and cell apoptosis, etc. For multicellular organisms, the ability to synchronize heterogeneous individual cellular responses through intercellular communication is crucial to maintain normal functionality. However, even though the biological pathways...
    Resource Type:
    Dissertation
    Full Text:
    everything. As early as 1982, John Hopfield provided a physicist’s answer to the neuron scientist’s question

  • Gene Activation Strategies in Filamentous Fungi for Natural Products Discovery

    Creator:
    Adpressa, Donovon A.
    Abstract:
    Fungi have long been a prolific source of clinically approved drugs. The antibiotic penicillin, the cholesterol lowering statins, and the immunosuppressant cyclosporine have changed the treatment of human diseases in the last century. Recently, genome analysis of filamentous fungi has revealed that the biosynthetic potential for natural product expression is...
    Resource Type:
    Dissertation

  • Human exposure to polycyclic aromatic hydrocarbons : global cancer risk and metabolism

    Creator:
    Motorykin, Oleksii
    Abstract:
    In recent decades, there has been increased attention on human exposure to, and subsequently toxicity of, Polycyclic Aromatic Hydrocarbons (PAHs). PAHs are widespread organic pollutants and some have been shown to be toxic, carcinogenic and mutagenic. This research was focused on understanding the link between global PAH emissions and lung...
    Resource Type:
    Dissertation

  • Multi-scale Investigation of Bidirectional Feedback Mechanism Between Breast Cancer Cells and Extracellular Matrix

    Creator:
    Kim, Jihan
    Abstract:
    Cell migration is fundamental for physiological processes such as immune re-sponses, wound healing and development. It is also a critical characteristic of metastatic cancer cells. An extensive amount of studies have focused on 2D sub-strates in order to understand the mechanism of cancer metastasis. However, much less is known about...
    Resource Type:
    Dissertation
    Full Text:
    Alobaidi performed confocal microscopy, sample preparation, and performed data analysis. Nicholas Scott

  • Innovative Bioanalytical Tools & Methods for Combinatorial Non-Coding RNA Analysis

    Creator:
    Zhang, Lulu
    Abstract:
    Recently researchers have discovered that groups of small non-coding RNAs (ncRNAs) play regulatory roles in gene expression and participate in various biological processes. For example, pathogenesis of many diseases, cell cycle regulation, and signaling pathways. Intracellular and live cell imaging of small ncRNA groups will reveal their relative expression levels...
    Resource Type:
    Dissertation
    Full Text:
    Ziebart, Margie Haak, Paula Weiss, and Kristi Edwards. I would like to thank my lab mates Nicholas

  • Use of Targeted and Non-Targeted Analysis to Study Complex PAH Environmental Mixtures

    Creator:
    Chibwe, Leah
    Abstract:
    Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous contaminants formed from the incomplete combustion of organic material. These contaminants are of concern because of their widespread presence in the environment and toxic properties. In addition, PAHs encompass a class of diverse compounds with varying physicochemical properties and exist in the environment as...
    Resource Type:
    Dissertation

  • Photophysics of organic semiconductors at the nanoscale

    Creator:
    Grollman, Rebecca R.
    Abstract:
    Organic semiconductors are used in a wide variety of applications including transistors,solar cells, and light emitting diodes. These materials are solution-processable,low cost, and tunable. Many successful organic optoelectronic materials utilizeblends of several types of molecules (such as donors and acceptors) in order topromote charge generation. As blends are an inherently...
    Resource Type:
    Dissertation

  • Computational nanooptics in hyperbolic metamaterials and plasmonic structures

    Creator:
    Thongrattanasiri, Sukosin
    Abstract:
    This dissertation concerns several problems in the fields of light interaction with nanostructured media, metamaterials, and plasmonics. We present a technique capable of extending operational bandwidth of hyperbolic metamaterials based on interleaved highly-doped InGaAs and undoped AlInAs multilayer stacks. The experimental results confirm theoretical predictions, exhibiting broadband negative refraction response...
    Resource Type:
    Dissertation
    Full Text:
    . I would like to thank one of our research group members, Nicholas A. Kuhta, for valuable

  • Subwavelength light confinement and quantum chaos in micro- and nano-structured metamaterials

    Creator:
    Govyadinov, Alexander A.
    Abstract:
    This dissertation concerns a broad range of unique phenomena related to the light propagation at nano- and micro-scales. To access the nano-domain, we introduce anisotropy-based waveguides with positive- and negative-index modes. These novel structures allow energy propagation in subwavelength regions and, in contrast to surface waves, have the mode structure...
    Resource Type:
    Dissertation
    Full Text:
    group, especially Robyn Wangberg, Justin Elser and Nicholas Kuhta, for valuable discussions and input

  • On the photoresponse of several novel oligoacene and anthradithiophene derivatives

    Creator:
    Day, Jonathan
    Abstract:
    The results of an investigation into carrier dynamics in several novel functionalized and solution-processable pentacene and anthradithiophene derivatives are reported. Measurements were made of real-time photoresponse of polycrystalline thin films of these materials to ultrafast laser pulses, on picosecond to microsecond time-scales, as well as measurements of dark current and...
    Resource Type:
    Dissertation
    Full Text:
    “functionalized” polyacenes. John Anthony and his group at the University of Kentucky investigated the