Index Catalog // ScholarsArchive@OSU

Ascorbylation- the biological relevance of covalently bound ascorbic acid

Creator:: Kesinger, Nicholas G.
Abstract:: Ascorbic acid, or vitamin C, is well known as a co-factor for proline-hydroxylase and as an anti-oxidant. However, it is also capable of forming covalent bonds, particularly in the role of a nucleophile, henceforth termed 'ascorbylation'. The ascorbylation of electrophiles can occur under physiological conditions. Furthermore, there are a number...
Resource Type:: Dissertation

Conformationally chiral diphenylethers and the enantioselective Ullmann etherification

Creator:: Salih, M. Quamar
Abstract:: Since the discovery of molecular chirality in 1848, this notion has had a substantial impact on medicine, biology, and chemistry. Extensive effort has been directed towards the construction of chiral molecules that contain sp³ hybridized stereogenic centers. In contrast, less effort has been dedicated to molecules that are chiral by...
Resource Type:: Dissertation
Full Text:: .!Nagai,!Chem.,Pharm.,Bull.!1997,!45,! 820.! 8!Toyota,!M.;! Yoshida,! T.;! Kan,! Y.;! Takaoka,! S

Functional transition metal oxides : structure-property relationships

Creator:: Smith, Andrew E.
Abstract:: Transition metal oxides are an important class of materials for the wide variety optical, electrical, dielectric, magnetic, and thermal properties observed. Their unique structure-property relationships allow for property tuning and often provide insight into the fundamentals of chemistry. The work in this thesis was focused on the design, synthesis and...
Resource Type:: Dissertation

Non-viral Vectors for Ocular Gene Delivery

Creator:: Herrera-Barerra, Marco, F.
Abstract:: Nucleic acid therapeutics has cemented itself as one of the most efficacious and robust avenues for treatment of a wide range of diseases from vaccine development to treatment of liver, retina, cancer applications. Non-viral mediated gene delivery using lipid-based nanoparticle (LNP) carriers has proven its compatibility with addressing unexpected, fast...
Resource Type:: Dissertation

Synthesis, characterization, and analysis of nitroaromatic compounds

Creator:: McIntosh, Melissa Luana
Abstract:: Nitroaromatic compounds have important chemical applications and can be found in nature as pollution sources. Synthetic nitroaromatic compounds have been used in a variety of materials including explosives, pharmaceuticals, dyes, plastics, and pesticides. These compounds can find their way into the environment through normal or improper disposal methods. Poly-aromatic compounds...
Resource Type:: Masters Thesis
Full Text:: .; Hutziger, O. Bull. Environ. Contam. Tox. 1970, 5, 565-568. 3. Musa Bandowe, B. A.; Meusel, H.; Huang, R

Biogeochemical Processing of Freshwater Carbon in the Anthropocene

Creator:: Buser, Jessica Z.
Abstract:: Freshwater systems cycle carbon along a spatial and temporal biogeochemical continuum, across which ecosystem processes contribute to transformations of organic matter (OM). Various ecological constraints impact rates OM transformation and production and consumption of the energetic end of respiration, methane. Microbiological processing and complete reduction of carbon substrates to methane...
Resource Type:: Dissertation

A Pyrone Diels–Alder Approach to Substituted Indoles and Carbazoles and the Synthesis of New Ropinirole Analogues

Creator:: Points, Gary L., III
Abstract:: Aromatic heterocycles are core structural motifs in natural products, pharmaceuticals and biological polymers. Indoles, in particular, represent a significant subclass of aromatic heterocycles, both in terms of sheer numbers, but also in biological and pharmaceutical relevance. As such, new methodologies for the synthesis of indoles represent an important and continually...
Resource Type:: Dissertation

Identification and characterization of type III effector proteins in plant-associated bacteria

Creator:: Thomas, William J.
Abstract:: Symbioses between microbes and multicellular eukaryotes are found in all biomes, and encompass a spectrum of symbiotic lifestyles that includes parasitism and disease, commensalism, and mutually beneficial interdependent host-microbe relationships. Regardless of outcome, these symbiotic lifestyles are governed by a complex molecular "courtship" between microbe and potential host. This courtship...
Resource Type:: Dissertation

Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

Creator:: Snyder, Kevin M.
Abstract:: In this report, three studies are presented that aid in the development of drug discovery and their synthesis. In each, the importance of the marriage between computations and experiments is highlighted. Continued efforts in this vein are essential for future efforts towards improving human health. The first case study investigated...
Resource Type:: Masters Thesis
Full Text:: !Hantzsch, A. Ann. 1882, 215, 1. 27!Mannich, C.; Krösche, W. (1912). "Ueber ein Kondensationsprodukt aus

ScholarsArchive@OSU

Ascorbylation- the biological relevance of covalently bound ascorbic acid

Conformationally chiral diphenylethers and the enantioselective Ullmann etherification

Functional transition metal oxides : structure-property relationships

Non-viral Vectors for Ocular Gene Delivery

Synthesis, characterization, and analysis of nitroaromatic compounds

Biogeochemical Processing of Freshwater Carbon in the Anthropocene

A Pyrone Diels–Alder Approach to Substituted Indoles and Carbazoles and the Synthesis of New Ropinirole Analogues

Identification and characterization of type III effector proteins in plant-associated bacteria

Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

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