Search Constraints

Start Over
Filtering by: Creator Hyer, Edgar A. Remove constraint Creator: Hyer, Edgar A. Committee Member McPhail, Kerry Remove constraint Committee Member: McPhail, Kerry

Search Results

  • Pactamycin Inspired Drug Discovery: A Synthetic and Chemoenzymatic Approach

    Creator:
    Brumsted, Corey J.
    Abstract:
    Pactamycin, first reported in 1962, is a potent antitumor antibiotic produced by the soil bacterium Streptomyces pactum. Structurally, it contains a cyclopentitol core unit, a 3-aminoacetophenone (3AAP), a 6-methylsalicylic acid (6-MSA), and a N,N-dimethyl urea. The aminocyclopentitol ring is derived from glucose, possibly via N-acetyl glucosamine (GlcNAc), the 3-aminoacetophenone (3AAP)...
    Resource Type:
    Dissertation
    Full Text:
    : Pactamycin Inspired Drug Discovery: A Synthetic and Chemoenzymatic Approach Abstract approved

  • Ascorbylation- the biological relevance of covalently bound ascorbic acid

    Creator:
    Kesinger, Nicholas G.
    Abstract:
    Ascorbic acid, or vitamin C, is well known as a co-factor for proline-hydroxylase and as an anti-oxidant. However, it is also capable of forming covalent bonds, particularly in the role of a nucleophile, henceforth termed 'ascorbylation'. The ascorbylation of electrophiles can occur under physiological conditions. Furthermore, there are a number...
    Resource Type:
    Dissertation
    Full Text:
    as a co-factor for proline- hydroxylase and as an anti-oxidant. However, it is also capable of

  • Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

    Creator:
    Huang, Lin
    Abstract:
    Oxidative stress is defined as an imbalance that favors the production of reactive oxygen species (ROS) over an organism's antioxidant defense. ROS have the ability to damage, either directly or indirectly, biomolecules including DNA, proteins, carbohydrates, and lipids. Various pathological conditions and environmental and chronic diseases have been associated with...
    Resource Type:
    Dissertation
    Full Text:
    acid side chains by reactive lipid peroxidation products (LPPs), a large variety of which are

  • Characterization of Neurospora crassa and Fusarium graminearum mutants defective in repeat-induced point mutation

    Creator:
    Pomraning, Kyle R.
    Abstract:
    Mutation of repetitive DNA by repeat-induced point mutation (RIP) is a process that occurs in many filamentous fungi of the Ascomycota during the sexual cycle. Concurrently, direct DNA repeats are often deleted by homologous recombination at high frequency during the sexual cycle. Thus, the processes of RIP and deletion compete...
    Resource Type:
    Dissertation
    Full Text:
    of repetitive DNA by repeat-induced point mutation (RIP) is a process that occurs in many

  • Single-Cell Genomics of Uncultivated Marine Bacteria

    Creator:
    Landry, Zachary
    Abstract:
    Historically, the difficulty of obtaining pure cultures of abundant marine microbial plankton has an obstacle to reconstructing the underlying mechanisms of biogeochemistry in the ocean. While a number of dominant marine species from the ocean surface have been cultured, the dominant microbial plankton of the dark ocean proved far more...
    Resource Type:
    Dissertation
    Full Text:
    ocean. While a number of dominant marine species from the ocean surface have been cultured, the