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Filtering by: Committee Member Meints, Russel H.

Regulation of ribonucleotide reductase analyzed by simultaneous measurement of the four enzyme activities

Creator:

Hendricks, Stephen P.

Abstract:

The first committed step in DNA biosynthesis occurs by direct reduction of ribonucleotides. This reduction is catalyzed by ribonucleotide reductase (RNR), an enzyme which uses a unique radical mechanism to facilitate the transformation. All four DNA precursors are synthesized by a single enzyme. Therefore, an intricate pattern of regulation has...

Resource Type:

Dissertation