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Filtering by: Creator Remcho, Vincent T. Remove constraint Creator: Remcho, Vincent T. Committee Member Ostroverkhova, Oksana Remove constraint Committee Member: Ostroverkhova, Oksana Degree Level Doctoral Remove constraint Degree Level: Doctoral

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  • Hydrogen/deuterium exchange mass spectrometry as a technology platform for studying conformational dynamics in large protein complexes

    Creator:
    Nirudodhi, Sasidhar N.
    Abstract:
    Proteins are essential to all biological systems. Proteins participate in numerous cellular processes by interacting with other proteins, other metabolites and membranes in a dynamic environment. Studying the structural and conformational properties of proteins in the solution phase is necessary to understand their protein folding and interaction dynamics. This research...
    Resource Type:
    Dissertation
    Full Text:
    . Victor Hsu, Dr. Vincent T. Remcho, Dr. Jan Frederik Stevens and Dr. Oksana Ostroverkhova. I would like

  • Applications of Holographic Optical Tweezers: Multiplexed Fluorescence Spectroscopy and the Micromechanics of Type-I Collagen

    Creator:
    Cibula, Matthew A.
    Abstract:
    The development and some applications of holographic optical tweezers (HOT) are presented. Our HOT system uses a spatial light modulator (SLM) to control the location and properties of the optical trap. We have developed a method for optimizing the diffraction efficiency of a SLM that can be applied in situ...
    Resource Type:
    Dissertation
    Full Text:
    = − , (2.3) ∂t ∂D \ × H = Jf + , (2.4) ∂t where D, B, E, and H are the displacement field, magnetic

  • Liquid-gated carbon nanotube transistor noise sources and sensitivity limits

    Creator:
    Sharf, Tal
    Abstract:
    Low-dimensional electronic materials offer a platform to observe biological processes with unprecedented spatial and temporal resolution. Carbon nanotubes (CNTs) are the closest physical analog to an ideal 1D system and can be scaled and integrated into multiplexed electronic circuitry. The molecular structure of a CNT is also biocompatible, making them...
    Resource Type:
    Dissertation
    Full Text:
    . Biosensing 1) M. R. Leyden, C. Schuman, T. Sharf, J. W. Kevek, V. T. Remcho, and E.D. Minot, 'Fabrication

  • Label free biosensing with carbon nanotube transistors

    Creator:
    Leyden, Matthew R.
    Abstract:
    As electronics reach nanometer size scales, new avenues of integrating biology and electronics become available. For example, nanoscale field-effect transistors have been integrated with single neurons to detect neural activity. Researchers have also used nanoscale materials to build electronic ears and noses. Another exciting development is the use of nanoscale...
    Resource Type:
    Dissertation
    Full Text:
    group use his clean room, and Chris Tasker and Rick Presley for their help. Vince Remcho, and the

  • CoLocalized Excitation Emission Resolution : A CLEER approach for multicolor fluorescence analysis

    Creator:
    Almlie, C. Kyle
    Abstract:
    Fluorescence has proven to be a robust and powerful method of analysis in numerous fields: forensics, pharmaceutics, geology, food science, and environmental sciences have all developed a large collection of fluorescence instruments and methods to overcome application-specific challenges. Biological applications saw the same development of a fluorescence toolkit with methods...
    Resource Type:
    Dissertation
    Full Text:
    to support me: Drs. Vince Remcho, Paul Cheong, Michael Burand, and Neal Sleszynski have all been

  • Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

    Creator:
    Otto, Shauna C.
    Abstract:
    Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...
    Resource Type:
    Dissertation
    Full Text:
    how Ca2+ binding can alter the properties of the domain. 9 T ab le 1. 1: C al ci u m b in d in

  • DC/AC Stability of In-Ga-Zn-O Thin-Film Transistors

    Creator:
    Zhou, Fan
    Abstract:
    The electrical stability of amorphous indium-gallium-zinc oxide (a-IGZO) thinfilmtransistors (TFTs) is investigated for flat-panel display applications. Althoughproducts incorporating a-IGZO TFT backplanes are already commercially available,e.g., iMac with 5K retina display, technical challenges need to be addressed for nextgenerationapplications, e.g., active-matrix organic light-emitting diode displays.Device stability is one crucial issue. The...
    Resource Type:
    Dissertation
    Full Text:
    -exponential over this range of stress time. ….….….….…………74 Figure 5.2 Stretched-exponential fits to ΔVTH(t

  • Terahertz imaging and spectroscopy of carbon-based and semiconductor nanostructures

    Creator:
    Tomaino, Joseph L.
    Abstract:
    This thesis will cover work that I have completed relating to the field of terahertz (THz) science. My work has consisted of generating tunable, narrowband THz pulses in a table-top optical setup and using both narrow- and broadband THz pulses to study various material systems. Broadband THz pulses were used...
    Resource Type:
    Dissertation
    Full Text:
    Graphene+Si…..………………………….. 41 2.5 Transmission coefficient through a graphene thin film (t

  • Multi-scale Investigation of Bidirectional Feedback Mechanism Between Breast Cancer Cells and Extracellular Matrix

    Creator:
    Kim, Jihan
    Abstract:
    Cell migration is fundamental for physiological processes such as immune re-sponses, wound healing and development. It is also a critical characteristic of metastatic cancer cells. An extensive amount of studies have focused on 2D sub-strates in order to understand the mechanism of cancer metastasis. However, much less is known about...
    Resource Type:
    Dissertation
    Full Text:
    persistent length lp , which are connected to each other. Each rod has radius of R. t⃗(s) represents

  • Efficient Private Matching for Private Databases

    Creator:
    Trieu, Thi Ni Ni
    Abstract:
    Private matching (PM) is a key cryptographic primitive in secure computation that allows several parties to jointly compute some functions depending on their private inputs. Indeed, this primitive has many practical applications. For instance, in online advertising, two companies may wish to find their common customers for a joint marketing...
    Resource Type:
    Dissertation
    Full Text:
    described in the table to the right. . . . . . . . . 94 4.1 The OPPRF ideal functionality FF,t,nopprf