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Filtering by: Creator Frey%2C Paul Reheard Remove constraint Creator: Frey%2C Paul Reheard Committee Member Ostroverkhova, Oksana Remove constraint Committee Member: Ostroverkhova, Oksana

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  • Analysis of the mechanism of sulfoxide-lithium exchange and the reactive intermediate in stereospecific reagent-controlled homologation (StReCH)

    Creator:
    Hoyt, Amanda
    Abstract:
    The stereospecific reagent-controlled homologation (StReCH) of boronic esters with enantioenriched carbenoid species generated in situ by the addition of organolithium initiators to stereodefined α-chloroalkyl aryl sulfoxides was previously reported. The reaction of an organolithium with an α-chloroalkyl aryl sulfoxide ostensibly generates an α-chloroalkyllithium via sulfoxide-lithium exchange; however, the true nature...
    Resource Type:
    Masters Thesis
    Full Text:
    : Paul R. Blakemore The stereospecific reagent-controlled homologation (StReCH) of boronic esters

  • Total Synthesis of Isotopologues of Xanthohumol and its Congeners for Biological Studies

    Creator:
    Plagmann, Layhna S.
    Abstract:
    Xanthohumol [XN, (E)-6´-methoxy-3´-(3-methylbuten-2-yl)-2´,4´,4´´-trihydroxychalcone], the principal prenylated chalcone from hops, and its 2,3-dihydro- (DXN) and O6-desmethyl-2,3-dihydro- (DDXN) congeners, are of potential utility for the amelioration of metabolic syndrome; however, their complex bioactivity profiles cannot be properly studied and understood without access to appropriately produced synthetic materials. In the first part of...
    Resource Type:
    Masters Thesis
    Full Text:
    Isotopologues of Xanthohumol and its Congeners for Biological Studies Abstract approved: Paul

  • Total synthesis of sparteine alkaloids from a common tetraoxobispidine intermediate

    Creator:
    Melbardis, John
    Abstract:
    In previous work (Blakemore et al. Org. Lett. 2005, 7, 4721; Heterocycles 2006, 70, 609), successful elaborations of the lupine alkaloids (±)-α-isosparteine (dl-2) and (±)-β-isosparteine (dl-3) were realized from a common tetraoxobispidine precursor, 3,7-diallyl -2,4,6,8-tetraoxo-3,7-diazabicyclo[3.3.1]nonane (93). Herein, the tetraoxobispidine approach to lupine alkaloids was extended to a total synthesis of...
    Resource Type:
    Masters Thesis
    Full Text:
    Tetraoxobispidine Intermediate Abstract approved: Paul R. Blakemore In previous work (Blakemore et al

  • Synthesis and catalytic applications of derivatives of 7,7'-dihydroxy-8,8'-biquinolyl (azaBINOL)

    Creator:
    Wang, Chao
    Abstract:
    The synthesis of axially chiral polyfunctional derivatives of 8,8'-biquinolyl was explored and the catalytic action of appropriate derivative types investigated in three separate processes: (1) the silylcyanation of carbonyl groups and imines, (2) alkylation of a glycine Schiff-base via phase transfer-catalysis, and (3) direct amide bond formation from simple amines...
    Resource Type:
    Dissertation
    Full Text:
    : Paul R. Blakemore The synthesis of axially chiral polyfunctional derivatives of 8,8´-biquinolyl

  • Cis-2,5-diaminobicyclo[2.2.2]octane : a novel C₂-symmetric scaffold for asymmetric catalysis

    Creator:
    Shaw, Subrata
    Abstract:
    This thesis describes the development of a new enantioselective synthetic method employing chiral cis-2,5-diaminobicyclo[2.2.2]octane-based organometallic catalysts. The significance of this new method to organic synthesis is illustrated with preparation of enantioenriched products that are transformed to important pharmaceutical agents. Chapter 1 provides a brief historical overview of asymmetric catalysis, especially...
    Resource Type:
    Dissertation
    Full Text:
    obliged to Professor Rich G. Carter, Paul R. Blakemore and Kevin P Gable from the Department of Chemistry

  • Terahertz Imaging and Nonlinear Spectroscopy of Semiconductors using Plasmonic Devices

    Creator:
    Thompson, Zachary James
    Abstract:
    In this dissertation, a series of studies in the field of terahertz (THz) science are presented, specifically using nonlinear THz spectroscopy. We exploit huge field enhancement and subwavelength confinement in plasmonic structures. There are three distinct projects which will be discussed: nonlinear THz spectroscopy using plasmonic induced transparency (PIT), THz-triggered...
    Resource Type:
    Dissertation
    Full Text:
    to thank my group members Michael Paul, Andrew Stickel, Byounghwak Lee, and Ali Mousavian for their

  • Liquid-gated carbon nanotube transistor noise sources and sensitivity limits

    Creator:
    Sharf, Tal
    Abstract:
    Low-dimensional electronic materials offer a platform to observe biological processes with unprecedented spatial and temporal resolution. Carbon nanotubes (CNTs) are the closest physical analog to an ideal 1D system and can be scaled and integrated into multiplexed electronic circuitry. The molecular structure of a CNT is also biocompatible, making them...
    Resource Type:
    Dissertation
    Full Text:
    suspended CNT devices for this project. 5) M. J. Paul, N. A. Kuhta, J. L. Tomaino, A. D. Jameson, L. P

  • Efficient Private Matching for Private Databases

    Creator:
    Trieu, Thi Ni Ni
    Abstract:
    Private matching (PM) is a key cryptographic primitive in secure computation that allows several parties to jointly compute some functions depending on their private inputs. Indeed, this primitive has many practical applications. For instance, in online advertising, two companies may wish to find their common customers for a joint marketing...
    Resource Type:
    Dissertation

  • Electronic and Optical Properties of Defects in Amorphous Oxide and Transition Metal Dichalcogenide Semiconductors

    Creator:
    Vogt, Kyle
    Abstract:
    The optical and electronic properties of amorphous oxide thin films depend crucially on chemical composition, and deposition process variations which give rise to sub-gap defect states. Consequently, there is a need for a reliable, high-throughput method to extract sub-gap defect densities of states in amorphous oxide thin films. We present...
    Resource Type:
    Dissertation
    Full Text:
    chemistry. Paul Cheong was the PI leading the chemistry team. John Wager had an immense impact on the

  • BaCuChF (Ch = S, Se, Te) p-type transparent conductors

    Creator:
    Zakutayev, Andriy
    Abstract:
    BaCuChF (Ch = S, Se, Te) materials are chalcogen-based transparent conductors with wide optical band gaps (2.9 – 3.5 eV) and a high concentration of free holes (10¹⁸ – 10²⁰ cm⁻³) caused by the presence of copper vacancies. Chalcogen vacancies compensate copper vacancies in these materials, setting the Fermi level...
    Resource Type:
    Dissertation
    Full Text:
    with: Robert Kykyneshi, Heather Platt, Annette Richard, Paul Newhouse, Kai Jiang, Daniel Harada, Josh