Index Catalog // ScholarsArchive@OSU

Detection, biosynthesis, and structural investigations of naturally occurring alkynes and other microbial metabolites

Creator:: Back, Daniel C.
Abstract:: Natural products have long been an important source of resources for humans. Many of these compounds possess unique chemical structures and potent biological properties. By targeting natural products with specific chemical properties, we can gain a better understanding of the roles these compounds play in the environment and their interactions...
Resource Type:: Dissertation

Gene Expression, Structure Elucidation, and Bioactivity of Aspergillus Natural Products

Creator:: Neuhaus, George F.
Abstract:: The study of natural products (NPs) and their application has shaped humanity. Starting with the idea of using plants as medicine, it has now grown into the science of purifying and identifying organic molecules from nature to study their inherent biological activities. Understanding the molecular structures of NPs is the...
Resource Type:: Dissertation

Bioactive Microbial Natural Products from Unique Indonesian Black Water Ecosystems

Creator:: Sheng, Yan
Abstract:: The discovery of new antibiotics reached its peak during the golden era of antibiotics in the mid 20th century and continued to thrive until the 1980s. However, after more than 50 years of fruitful exploration and exploitation of microbial natural products the discovery rate of new antibiotics has dropped drastically...
Resource Type:: Dissertation

Development of Novel Agents to Combat Tuberculosis and Malaria

Creator:: Almabruk, Khaled Husain G.
Abstract:: Despite the advance of biomedical science, infectious diseases remain one of the number one killers in the world. They claim the lives of millions of people annually, particularly in underdeveloped and developing countries. In fact, more than 32% of the health burden in Africa is caused by infectious diseases, e.g.,...
Resource Type:: Dissertation

Biologically active metabolites from marine microorganisms : methods to identify drug leads and chemical signals

Creator:: Vining, Oliver B.
Abstract:: Microbial natural products represent a massive repository of unique chemical scaffolds with corresponding diverse biological functions. However, in the past decade the development of natural products into new therapeutics has dwindled, in part due to the challenges posed by high rediscovery rates and low throughput associated with classical bioassay-guided fractionation...
Resource Type:: Dissertation

The effect of ascorbate on enzymatic nitroglycerin bioactivation as measured by direct LC-MS/MS determination of nitrite

Creator:: Hardardt, Elizabeth Ann
Abstract:: This work sought to characterize a link between Vitamin C and nitroglycerin at the level of enzymatic bioactivation. Before we could proceed, we needed to develop a method that sensitively and selectively identified the product of bioactivation, nitrite. We successfully adapted traditional diaminonaphthalene derivatization with the use of stable isotope...
Resource Type:: Masters Thesis

Bioactive natural products from marine algae

Creator:: Tan, Lik Tong
Abstract:: This thesis is an account of my investigation on the natural products deriving from various marine algae and has resulted in the discovery of thirteen novel bioactive metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D...
Resource Type:: Dissertation

Steps toward structure-assisted drug design

Creator:: Watts, K. Shawn
Abstract:: The three dimensional structure of both a ligand and its cognate receptor are required for the success of structure-assisted drug design. This thesis reports the crystal structure of hectochlorin, a small, bioactive molecule, and the steps toward determining the crystal structure of an RNA molecule that is an attractive target...
Resource Type:: Masters Thesis

Host selection, reproductive biology, host-specific development and mortality of the codling moth, Cydia pomonella (L.) (Lepidoptera: Torticidae), in apple and pear

Creator:: Marti, Santiago Marti
Abstract:: The biology and behavior of the codling moth, Cydia pomonella (L.), was studied to determine factors responsible for differences in susceptibility to moth damage among apple and pear cultivars. In release experiments, codling moth adults were intercepted in significantly greater numbers in host (apple, pear) than in non-host (maple) trees,...
Resource Type:: Dissertation

Marine algal secondary metabolites of unique structure and biomedicinal or agrichemical potential

Creator:: Milligan, Kenneth Edward
Abstract:: This thesis describes investigations of marine algal secondary metabolites, with particular interest in their biomedical and agrichemical potential. Invaluable in such pursuits have been the access and application of advanced spectroscopic techniques, such as NMR, and the ability to assess the biological activity of the algal samples in a variety...
Resource Type:: Dissertation

ScholarsArchive@OSU

Detection, biosynthesis, and structural investigations of naturally occurring alkynes and other microbial metabolites

Gene Expression, Structure Elucidation, and Bioactivity of Aspergillus Natural Products

Bioactive Microbial Natural Products from Unique Indonesian Black Water Ecosystems

Development of Novel Agents to Combat Tuberculosis and Malaria

Biologically active metabolites from marine microorganisms : methods to identify drug leads and chemical signals

The effect of ascorbate on enzymatic nitroglycerin bioactivation as measured by direct LC-MS/MS determination of nitrite

Bioactive natural products from marine algae

Steps toward structure-assisted drug design

Host selection, reproductive biology, host-specific development and mortality of the codling moth, Cydia pomonella (L.) (Lepidoptera: Torticidae), in apple and pear

Marine algal secondary metabolites of unique structure and biomedicinal or agrichemical potential

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