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Filtering by: Creator Parker, Edgar J. Remove constraint Creator: Parker, Edgar J. Committee Member Qiu, Weihong Remove constraint Committee Member: Qiu, Weihong Degree Level Doctoral Remove constraint Degree Level: Doctoral Rights Statement In Copyright Remove constraint Rights Statement: In Copyright

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  • Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

    Creator:
    Baker, Kasie J.
    Abstract:
    The Hippo signaling pathway is an evolutionarily conserved regulator of cell growth, proliferation, and apoptosis. A key function of the pathway is to regulate the subcellular distribution and activity of Yorkie in Drosophila or Yes-associated protein (YAP) and transcription co-activator with PDZ-binding motif (TAZ) in mammals. The dysregulation of the...
    Resource Type:
    Dissertation
    Full Text:
    THE DISSERTATION OF Kasie J. Baker for the degree of Doctor of Philosophy in Biochemistry and

  • Single-molecule in vitro Characterization of Otoferlin

    Creator:
    Hams, Nicole J.
    Abstract:
    Congenital hearing loss is a common disorder and over 60 mutations in the sensory hair cell protein, otoferlin, have been linked to pre-lingual deafness. Although otoferlin is essential for hearing, the large size and low solubility of the protein have limited approaches to study its function on a molecular-level. To...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Nicole J. Hams for the degree of Doctor of Philosophy in

  • In vivo Reactions of Tetrazines Incorporated through Genetic Code Expansion

    Creator:
    Blizzard, Robert J.
    Abstract:
    The inverse electron demand Diels Alder reaction between tetrazines and strained alkenes is an exceptionally useful tool in functionalizing to biomolecules since it is orthogonal to the chemistry of most living systems and have exceptionally high rate constants. In particular reactions between strained trans-cyclooctenes (sTCO) and tetrazines can achieve second...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Robert J

  • Host and Pathogen Genetics in the Sharp Eyespot Disease of Wheat

    Creator:
    Liu, Jiang
    Abstract:
    Wheat sharp eyespot (SES), caused by the soil-borne fungus Rhizoctonia cerealis is a common stem disease of wheat globally. The disease caused a severe and extensive epidemic throughout the Willamette Valley of Oregon in 2014 and has remained one of the most important wheat diseases in this region. However, litte...
    Resource Type:
    Dissertation
    Full Text:
    . Chen J, Li GH, Du ZY et al., 2013. Mapping of QTL conferring resistance to sharp eyespot (Rhizoctonia

  • Coulomb Explosion in Moderately Intense Nanosecond Laser Fields

    Creator:
    Yao, Yuzhong
    Abstract:
    In this dissertation, I present experimental observations of multiply charged atomic ions (MCAI) generated from interactions of atomic/molecular clusters with moderately intense nanosecond laser pulses. This process is also known as Coulomb explosion (CE) and it has been extensively studied in intense laser fields using ultrashort pulses. Several prevailing theories...
    Resource Type:
    Dissertation
    Full Text:
    , adapted from J. Phys. B: At., Mol. Opt. Phys. 39, R39 (2006). Fig. 1.1 presents a general scheme of

  • Part I: Synthetic Studies Towards Viridin, Halenaquinone, and Obtusanal. Part II: Analysis, Synthesis, and Characterization of Coronene Derivatives.

    Creator:
    Waldenmaier, Pieter K.
    Abstract:
    This thesis is separated into three distinct projects. First, synthetic studies towards the furanosteroid viridin shown in part I. Second, synthetic studies towards the diperene obtusanal shown in part II. Third, the analysis, characterization, and synthesis of coronene derivatives towards their application in organic batteries shown in part III. Significant...
    Resource Type:
    Dissertation
    Full Text:
    .; McKinnon, M.; Waterfield, M. D.;Parker, P. J. FEBS Lett. 1994, 342, 109-112. 11 Wipf, P.; Minion, D. J

  • CoLocalized Excitation Emission Resolution : A CLEER approach for multicolor fluorescence analysis

    Creator:
    Almlie, C. Kyle
    Abstract:
    Fluorescence has proven to be a robust and powerful method of analysis in numerous fields: forensics, pharmaceutics, geology, food science, and environmental sciences have all developed a large collection of fluorescence instruments and methods to overcome application-specific challenges. Biological applications saw the same development of a fluorescence toolkit with methods...
    Resource Type:
    Dissertation

  • Electron Diffraction of Neutral and Cationic Clusters Doped into Superfluid Helium Droplets

    Creator:
    Lei, Lei
    Abstract:
    In this dissertation, I describe the experimental investigation of electron diffraction of neutral and ionic clusters doped into superfluid helium droplets. The project is aimed at contributing to the development of an overall approach called ‘serial single molecule electron diffraction imaging (ss-EDI), a potential approach to solve macromolecule structures bypassing...
    Resource Type:
    Dissertation
    Full Text:
    helium droplets. 11 1.4 REFERENCE 1. Voet, D.; Voet, J. G.; Pratt, C. W., Fundamentals

  • Exploring Protein Structure: Seeing the Forest and the Trees

    Creator:
    Brereton, Andrew E.
    Abstract:
    Life on Earth intimately depends on the function of countless proteins. For the majority of studied proteins, function absolutely depends on conformation (i.e. 3-dimensional shape in solution). The exact nature of how a protein goes from an unfolded linear polypeptide chain to an organized folded molecule is still not known,...
    Resource Type:
    Dissertation

  • Bridging the Gap Between Equilibrium Properties and Ultrafast Dynamics with Time-Resolved Spectroscopy of Functional Systems

    Creator:
    Krueger, Taylor D.
    Abstract:
    Ultrafast spectroscopy has recently gained momentum as a powerful, noninvasive characterization toolset capable of studying a diverse array of samples with applications in chemistry, physics, biology, engineering, and more. Two popular ultrafast spectroscopic techniques include femtosecond transient absorption (fs-TA) and femtosecond stimulated Raman spectroscopy (FSRS). The latter of these techniques...
    Resource Type:
    Dissertation