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Creator:: Nguyen, Paulina M.
Abstract:: Studies have established that there is a greater risk for onset of adult metabolic syndrome disease such as diabetes mellitus, hypertension, hyperlipidemia, and obesity in subjects born with low birth weight (LBW). Undernourished fetuses make adaptions that result in structurally, morphologically, and functionally altered organs. In terms of drug pharmacokinetics,...
Resource Type:: Honors College Thesis
Full Text:: 5. Images of western blotting of microsomal fraction for Day 150 samples. OCT2 and β-actin bands

Creator:: Sather, Bergen K.
Abstract:: Type-2 diabetes (T2D) has become a pandemic. The main impairment in T2D is skeletal muscle insulin resistance (IR) and is often associated with obesity. Despite decades of study, the mechanisms of IR have not been fully resolved. Evidence has implicated mitochondrial dysfunction as a potential cause and/or consequence of IR....
Resource Type:: Honors College Thesis
Full Text:: Bergen Sather May 18, 2018 All Rights Reserved 5 Characterization of the Cellular

Creator:: Burney, Emily R.
Abstract:: The prevalence of obesity is increasing worldwide, causing a subsequent increase in insulin resistance (IR), metabolic disorders, and cardiovascular diseases. Although these conditions significantly impact both the individual and society, their etiologies have not been discovered, inhibiting potential prevention and treatment. Alterations to mitochondrial metabolism are implicated in the development...
Resource Type:: Honors College Thesis
Full Text:: secretion from the pancreas due to the blunted response to the initial release of insulin (11), (5). As

Creator:: Lin, Lisa
Abstract:: Koi herpesvirus (KHV), is a highly pathogenic virus causing high mortality in common carp and koi, especially in fry. One of the unique features of herpesvirus infections is their ability to become latent following initial infection. During latent infection, only viral genome persists in the host and remains dormant in...
Resource Type:: Honors College Thesis

Creator:: Kim, Joseph Y.
Abstract:: Antisense morpholino oligomers are synthetic macromolecules can modify gene expression. While these compounds have great potential to treat a broad range of human diseases, they suffer from poor cellular delivery. Conjugating cell-penetrating peptides onto these morpholinos is one option of addressing delivery, however development remains slow due to the cost...
Resource Type:: Honors College Thesis
Full Text:: cannot be degraded in human serum, cells [4], and tissue lysates [5]. 2 Figure 1. A side

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