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Filtering by: Creator Amarasinghe, Upali S. Remove constraint Creator: Amarasinghe, Upali S. Committee Member Reardon, Patrick Remove constraint Committee Member: Reardon, Patrick

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  • The Various Roles of LC8, a Human Hub Protein, in the Viral Replication Cycle

    Creator:
    Donner, Brianna L.
    Abstract:
    The phosphoprotein (P protein) in viruses of the Mononegavirales order is known to play an essential role in the completion of viral replication mechanisms. The P protein is involved in stabilizing the viral polymerase and nucleoprotein during RNA transcription and replication, regulating nascent RNA encapsidation by the nucleoprotein, and mediation...
    Resource Type:
    Honors College Thesis
    Full Text:
    occurs in the cytosol (Amarasinghe et al., 2019). Common childhood diseases caused by human

  • Specificity, Allostery, and Multivalency in Binding to the Hub Protein LC8

    Creator:
    Estelle, Aidan B.
    Abstract:
    Interactions between proteins are essential to life, driving and regulating a majority of processes within all living cells. Study of protein-protein interactions reveals that some proteins act as hubs within networks of interactions, binding to many partner proteins. These hubs therefore are of particular importance to understanding protein function, interwoven...
    Resource Type:
    Dissertation
    Full Text:
    T->S,I,V and Q->N,M,L are tolerated without abolishing binding, although motifs only rarely