Index Catalog // ScholarsArchive@OSU

The role of chlamydial inclusion membrane proteins in host-pathogen interaction and the development of novel methods for studying chlamydial biology

Creator:: Alzhanov, Damir T.
Abstract:: The majority of our modern understanding of bacterial pathogenesis is based on the strategy that involves screening bacterial genomes for the presence of the genes encoding pathogenic factors, and analysis of these genes via forward and reverse genetics. Chlamydiae represent a unique group of pathogenic bacteria in which it is...
Resource Type:: Dissertation
Full Text:: Daniel D. Rockey The majority of our modern understanding of bacterial pathogenesis is

Recombinant vaccines against infectious hematopoietic necrosis virus : bacterial systems for vaccine production and delivery

Creator:: Simon, Benjamin E.
Abstract:: Several systems were examined for the production and delivery of recombinant vaccines for fish. C. crescentus was employed to produce a fragment of the IHNV glycoprotein. When administered by injection to 0.5 gram rainbow trout (Oncorhynchus mykiss), one of the fusion proteins (184 amino acids of the IHNV glycoprotein fused...
Resource Type:: Dissertation
Full Text:: graduate committee members, especially Dr. Lyle Brown and Dr. Daniel Rockey, for stimulating discussions

Characterization of a Sporulation-Specific Kinase in Clostridium perfringens

Creator:: Danielson, Bryan
Abstract:: Clostridium perfringens type A isolates produce the spore-specific enterotoxin, CPE, upon sporulation in the gastrointestinal tract of humans and animals. Spo0A is a response regulator representing the major transcription factor for sporulation initiation in C. perfringens. In Bacillus subtilis, a multicomponent phosphorelay involving five histidine kinases (KinA-KinE), the intermediate response...
Resource Type:: Undergraduate Thesis and Presentation

The Inhibitory Activity of Essential Oil Constituents Against Clostridium perfringens Type A Isolates

Creator:: Alanazi, Saud
Abstract:: C. perfringens type A isolates are the causative agents of C. perfringens type A food poisoning (FP) and non-food-borne (NFB) human gastrointestinal diseases. In this study, we evaluated the antimicrobial effect of essential oil constituents (cinnamaldehyde, eugenol, allyl isothiocyanate (AITC), and carvacrol) against C. perfringens FP and NFB isolates grown...
Resource Type:: Masters Thesis
Full Text:: Mahfuzur R. Sarker Clostridium perfringens is a gram-positive spore forming bacterium that

Inactivation Strategy for Clostridium perfringens Spores Adhered onto Stainless Steel Surfaces

Creator:: Alzubeidi, Yasmeen S.
Abstract:: Clostridium perfringens is a spore-forming pathogenic bacterium that causes a variety of diseases in human and animals. C. perfringens type A isolates produce enterotoxin (CPE) causing food poisoning (FP) and non-food-borne (NFB) gastrointestinal (GI) diseases including antibiotic-associated diarrhea and sporadic diarrhea. C. perfringens type A food poisoning currently ranks as...
Resource Type:: Masters Thesis
Full Text:: : Mahfuzur R. Sarker Clostridium perfringens is a spore-forming pathogenic bacterium that causes a

New Insights into the Molecular Mechanism of Clostridium perfringens Spore Germination

Creator:: Banawas, Saeed S.
Abstract:: C. perfringens is a spore-forming, gram-positive, anaerobic pathogenic bacterium capable of causing a wide variety of diseases in both humans and animals. However, the two most common illnesses in humans are C. perfringens type A food poisoning (FP) and non-food-borne (NFB) gastrointestinal (GI) illnesses. Interestingly, these two major diseases are...
Resource Type:: Dissertation
Full Text:: . CONTRIBUTION OF AUTHORS Chapter 2: Dr. Mahfuzur R. Sarker and Dr. Daniel Paredes-Sabja contributed to the

Clostridium perfringens spores : inactivation, germination, and formation

Creator:: Udompijitkul, Pathima
Abstract:: The enterotoxin-producing Clostridium perfringens type A isolates are responsible for the third most common foodborne illness in the United States and can also cause non-foodborne human gastrointestinal (GI) diseases such as antibiotic- associated and sporadic diarrheas. Three important factors contribute to the ability of C. perfringens to cause GI diseases,...
Resource Type:: Dissertation
Full Text:: : __________________________________________________________________ Mahfuzur R. Sarker The enterotoxin-producing Clostridium perfringens type A isolates are

Inhibition of Clostridium perfringens spore growth by synergistic effects of different antimicrobials

Creator:: Alhabeeb, Rabiaa
Abstract:: Clostridium perfringens is a spore-forming anaerobic organism that is commonly present in fresh meat and poultry. The organism's spores can survive a range of food processing methods. C. perfringens type F isolates are the causative agents of C. perfringens type F food poisoning (FP) and non-food borne (NFB) human gastrointestinal...
Resource Type:: Masters Thesis
Full Text:: Abstract approved: ______________________________________________________ Mahfuzur R. Sarker

Evolutionary Genomic Responses to Mitochondrial Dysfunction in Caenorhabditis elegans

Creator:: Wernick, Riana I.
Abstract:: Understanding the impact of mitochondrial dysfunction on genome evolution has the potential not only to provide new insights on the basic evolutionary processes influencing mitochondrial and nuclear genomes, but may also reveal novel avenues for evolutionary adaptive recovery from harmful mutations. Aberrant mitochondrial activity is fundamental to the pathology of...
Resource Type:: Dissertation
Full Text:: elegans Abstract approved: ______________________________________________________ Dee R. Denver

Structural studies of the antioxidant defense enzymes; copper, zinc superoxide dismutase and alkyl hydroperoxide reductase flavoprotein

Creator:: Roberts, Blaine R.
Abstract:: Oxygen derived radicals are involved in many aspects of life from aging and cell signaling to disease states as diverse as heart disease, diabetes, neurodegeneration and inflammation. Therefore, understanding the function of antioxidant defense proteins and the effects of oxygen derived radicals on protein function is essential to elucidate the...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE THESIS OF Blaine R. Roberts for the degree of Doctor of Philosophy in

Investigation of unique marine environments for microbial natural products

Creator:: Thornburg, Christopher C.
Abstract:: Metagenomics has revealed that the marine microbial biosphere is immensely more diverse than originally considered, and is an almost untapped reservoir for the potential discovery of microbial natural products. Despite numerous advances in culturing, biosynthetic engineering and genomic-based screening efforts to uncover much of this diversity in relatively accessible environments,...
Resource Type:: Dissertation
Full Text:: external committee members, Dr. Martin Schuster and Dr. Daniel Rockey for your time and assistance during

Characterization of an inhibitor ("6S") of infectious pancreatic necrosis virus (IPNV) in normal rainbow trout serum (RTS) and its effects on the virus

Creator:: Park, Kyoung Chul
Abstract:: The characteristics of an inhibitor of infectious pancreatic necrosis virus (IPNV) found in normal rainbow trout serum (RTS) were studied. The serum inhibitor had a molecular weight of approximately 150 kDa and was dependent on divalent cations, either Ca²⁺ or Mg²⁺. It was stable at temperatures up to 50°C and...
Resource Type:: Dissertation
Full Text:: -R). Enzyme immunodot assay revealed that Ja-S clones and Ja-R clones differed by several epitopes

Characterization of germinant receptors in Clostridium perfringens non-food-borne isolates

Creator:: Banawas, Saeed S.
Abstract:: C. perfringens is a Gram-positive, spore-forming, anaerobic pathogenic bacterium capable of causing a wide variety of diseases in both humans and animals. However, the two most common illnesses in humans are C. perfringens type A food poisoning (FP) and non-food-borne (NFB) gastrointestinal (GI) illnesses . These two major diseases are...
Resource Type:: Masters Thesis
Full Text:: study. Dr. Mahfuzur R. Sarker and Dr. Daniel Paredes-Sabja contributed to the experimental design

Characterization of novel marine oligotrophic bacteria isolated from the Pacific Ocean : description of Marinivirgula fluito gen. nov., sp. nov., Marinivirgula obesa gen. nov., sp. nov. and Litincola parvulus gen. nov., sp. nov.

Creator:: Shin, Eun Jung
Abstract:: A new high-throughput culturing (HTC) method using a low nutrient heterotrophic medium (LNHM) has led to the isolation of many novel strains of oligotrophic bacteria from marine ecosystems. Four strains belonging to a single dade, HTCC2151, HTCC218OT, HTCC2178T and HTCC2188T, were isolated from the coast of Oregon by the HTC...
Resource Type:: Masters Thesis
Full Text:: acknowledge my committee members, Dr. Peter Bottomley, Dr. Daniel Rockey, and Dr. Julia Jones for their

Syntheses and evaluation of putative enzyme inhibitor of isoprenoid biosynthesis

Creator:: Phaosiri, Chanokporn
Abstract:: The discovery of the methylerythritol phosphate pathway (the MEP pathway) as an alternate pathway for isoprenoid biosynthesis in some organisms including most bacteria, malarial parasites and plants, but not in animals, has stimulated extensive studies in this area. Research has revealed the potential of finding novel antibacterials, antimalarial drugs, and...
Resource Type:: Dissertation
Full Text:: representative, Dr. Daniel Rockey for their support and inspiration. Thanks to the National Institutes of Health

Establishment of an in vitro System for Studying Mycobacterium avium Protein Secretion

Creator:: Chinison, Jessica J.
Abstract:: Cases of pulmonary diseases caused by Mycobacterium avium complex (MAC) have increased over the years and have become a major health concern in Europe, Asia, and the United States. MAC, comprised of M. avium species and M. intracellulare, are found everywhere in the environment: in water sources and the soil....
Resource Type:: Masters Thesis
Full Text:: the way.” Nat Rev Microbiol 5(11): 883-891. Aksamit, T. R., J. V. Philley, D. E. Griffith (2014

The MAV_4644 dual-function channel protein with putative ADP-ribosyltransferase activity of Mycobacterium avium is required for virulence within host macrophages

Creator:: Lewis, Matthew S.
Abstract:: Mycobacterium avium subspecies hominissuis (MAH) is an opportunistic pathogen that is ubiquitous in the environment and often isolated from faucets and showerheads. MAH mostly infects humans with an underlying disease, such as chronic pulmonary disorder (COPD), cystic fibrosis (CF), or are immunocompromised, though infections in patients without concurrent disease are...
Resource Type:: Masters Thesis
Full Text:: . avium subsp. avium 2285 (R) M. intracellulare MOTT-36Y M. intracellulare MOTT-02 M. intracellulare

Analysis of Betta splendens erythrophore responses to Bacillus cereus cultured in different media

Creator:: Austin, Melissa J.
Abstract:: Biological agents and their products commonly cause foodborne illnesses. In the United States it is estimated that there are over 76 million cases of foodborne illnesses each year, resulting in an economic loss of approximately $40 billion. These high figures demonstrate the need for bioassays that display a rapid and...
Resource Type:: Masters Thesis

Development of Novel Agents to Combat Tuberculosis and Malaria

Creator:: Almabruk, Khaled Husain G.
Abstract:: Despite the advance of biomedical science, infectious diseases remain one of the number one killers in the world. They claim the lives of millions of people annually, particularly in underdeveloped and developing countries. In fact, more than 32% of the health burden in Africa is caused by infectious diseases, e.g.,...
Resource Type:: Dissertation
Full Text:: found to have a virulence factor quenching activity in the plant pathogen Rhodococcus fascians. R

Biochemical Studies of Pactamycin Biosynthesis in Streptomyces pactum

Creator:: Eida, Auday
Abstract:: Ribomimetic natural products have long been known for their important biological activities. Structurally, they contain a densely functionalized cyclopentane unit that resembles ribose. Pactamycin, the prominent member of this class of natural products, is a potent protein synthesis inhibitor produced by the soil bacterium Streptomyces pactum. In pactamycin, the aminocyclopentitol...
Resource Type:: Dissertation
Full Text:: members: Dr. Kerry McPhail, Dr. Benjamin Philmus, Dr. Jane Ishmael, and Dr. Daniel Rocky for their

Exploring the cellular mechanisms of Cnidarian bleaching in the sea anemone Aiptasia pallida

Creator:: Perez, Santiago
Abstract:: Many members of the Phylum Cnidaria are mutualistic with unicellular dinoflagellates belonging to the genus Symbiodinium. Corals are the most widely recognized example of these associations due to their key ecological importance in coral reef ecosystems where they serve as the structural and trophic foundation of these rich ecosystems. Coral...
Resource Type:: Dissertation
Full Text:: hardships. I thank my committee, Lynda Ciuffetti, Daniel Rockey, Dahong Zhang and Alan Bakalinsky for

Characterization of microaggregate formation by Mycobacterium avium subspecies hominissuis

Creator:: Babrak, Lmar
Abstract:: Mycobacterium avium subsp hominissuis (MAH) is an opportunistic environmental pathogen that causes respiratory and gastrointestinal illness in immunocompromised persons such as those with chronic respiratory diseases or AIDs, respectively. In recent years, there has been a significant increase in the incidence of nontuberculous mycobacterial (NTM) lung infections, including in cystic...
Resource Type:: Dissertation
Full Text:: ........................ 162 Appendix 1.2 Bannatine JP, Everman JL, Rose SJ, Babrak L Katani R, Barletta RG, Talaat AM

Characterization of Mycobacterium avium subsp. hominissuis Interactions with Host Macrophages and Multinucleated Giant Cells

Creator:: Joseph, Jayanthi J.
Abstract:: To examine the macrophage response to M. avium, I compared inflammasome and cytosolic sensor expression and activation. My result demonstrated that virulent strains of M. avium (A5 and 104) suppress IL-1β production and induce IFN-β production in macrophages. M. avium mutants deficient at DNA export in the biofilm exhibited reduced...
Resource Type:: Dissertation
Full Text:: , Dr. Elain Fu, Dr. Daniel Rockey, and Dr. Martin Schuster for serving on my graduate committee

Infectious diseases of the Felidae : parasite communities from miniature to massive

Creator:: Broughton, Heather M.
Abstract:: Direct anthropogenic stressors have caused drastic declines in wildlife populations over the past two centuries. In the face of these threats, spillover of infectious disease from domestic animals and livestock into wildlife, and novel interactions between parasites and pathogens within wildlife communities, have further suppressed already vulnerable populations. As management...
Resource Type:: Dissertation
Full Text:: Software and R (MedCalc Statistical Software bvba, 2014; R Core Team, 14 2014). Prior to

Secondary Metabolism in Tolypocladium : Characterization, Ecology, Evolution and Regulation

Creator:: Blount, Rheannon Rua
Abstract:: An increased understanding of secondary metabolism in fungi is important for both biological and societal reasons. The ascomycete genus, Tolypocladium, is an ideal system to explore secondary metabolism characterization, ecology, evolution and regulation. The genus produces and has the genomic potential to produce a wide array of metabolites. Paired with...
Resource Type:: Dissertation
Full Text:: helped design, analyze and edit the study. Lanelle R. Connolly provided laboratory support and guidance

Further Understanding Mycobacterial Biofilms and Their Interaction with the Host

Creator:: Rose, Sasha J.
Abstract:: Respiratory infections caused by nontuberculous mycobacteria (NTM), especially Mycobacterium avium, can lead to progressive, recurrent disease that is refractory to therapy. Bacterial biofilms are intrinsically resistant to a variety of stressors and pressures, including host killing mechanisms and antibiotic therapy. Though it is becoming increasingly evident that NTM biofilms are...
Resource Type:: Dissertation
Full Text:: always been there to give her expertise and advise. I also want to thank Michael Kent, Daniel Rockey

Mechanistic Studies and Catalytic Engineering of the Pseudoglycosyltransferase VldE

Creator:: Abuelizz, Hatem A.
Abstract:: This thesis describes an investigation of the molecular basis of the substrate specificity and catalytic mechanism of a unique pseudoglycosyltransferase (PsGT) enzyme, VldE. PsGTs are a newly discovered group of glycosyltransferase (GT)-like proteins that catalyze the transfer of a pseudosugar to an acceptor molecule via a C-N bond formation. This...
Resource Type:: Dissertation
Full Text:: Stevens and Dr. Daniel D. Rockey for their invaluable cooperation. I also would like to thank King Saud

Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

Creator:: McNamara, Michael J.
Abstract:: Mycobacterium avium subsp. hominissuis (MAH) is a pervasive environmental bacterium that can cause opportunistic infections in humans. Among the most robust and hardy members of the Mycobacterium genus, M. avium can persist and thrive in a range of challenging environments, including many which place it in direct contact with humans....
Resource Type:: Dissertation
Full Text:: range of un- folded precursor proteins that contain a conserved N-terminal signal sequence (S/T- R-R-X

Molecular and cellular characterization of the intracellular phenotype of Mycobacterium avium

Creator:: Early, Julie V.
Abstract:: Mycobacterium avium cause disseminated disease in immunocompromised people such as AIDS patients. Subsequent to crossing the intestinal epithelium, M. avium thrive within vacuoles in macrophages. The bacteria exhibit a different, more invasive, phenotype after being in macrophages compared to M. avium from laboratory conditions. We hypothesized that this intracellular phenotype...
Resource Type:: Dissertation
Full Text:: thank my committee members: Daniel Rockey, Nancy Kerkvliet, Ling Jin, and Howard Gelberg for their

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