Index Catalog // ScholarsArchive@OSU

Molecular and cellular characterization of the intracellular phenotype of Mycobacterium avium

Creator:: Early, Julie V.
Abstract:: Mycobacterium avium cause disseminated disease in immunocompromised people such as AIDS patients. Subsequent to crossing the intestinal epithelium, M. avium thrive within vacuoles in macrophages. The bacteria exhibit a different, more invasive, phenotype after being in macrophages compared to M. avium from laboratory conditions. We hypothesized that this intracellular phenotype...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Julie V. Early for the

Characterization of Mycobacterium avium subsp. hominissuis Interactions with Host Macrophages and Multinucleated Giant Cells

Creator:: Joseph, Jayanthi J.
Abstract:: To examine the macrophage response to M. avium, I compared inflammasome and cytosolic sensor expression and activation. My result demonstrated that virulent strains of M. avium (A5 and 104) suppress IL-1β production and induce IFN-β production in macrophages. M. avium mutants deficient at DNA export in the biofilm exhibited reduced...
Resource Type:: Dissertation
Full Text:: and V-ATPase (Khandia et al., 2019). The final step in autophagosome maturation is fusion with

Biochemical Studies of Pactamycin Biosynthesis in Streptomyces pactum

Creator:: Eida, Auday
Abstract:: Ribomimetic natural products have long been known for their important biological activities. Structurally, they contain a densely functionalized cyclopentane unit that resembles ribose. Pactamycin, the prominent member of this class of natural products, is a potent protein synthesis inhibitor produced by the soil bacterium Streptomyces pactum. In pactamycin, the aminocyclopentitol...
Resource Type:: Dissertation

The MAV_4644 dual-function channel protein with putative ADP-ribosyltransferase activity of Mycobacterium avium is required for virulence within host macrophages

Creator:: Lewis, Matthew S.
Abstract:: Mycobacterium avium subspecies hominissuis (MAH) is an opportunistic pathogen that is ubiquitous in the environment and often isolated from faucets and showerheads. MAH mostly infects humans with an underlying disease, such as chronic pulmonary disorder (COPD), cystic fibrosis (CF), or are immunocompromised, though infections in patients without concurrent disease are...
Resource Type:: Masters Thesis
Full Text:: . Proteome Discoverer v 1.3.0, Mascot v 2.3 and Scaffold were used for data analysis. The Uniprot Homo

Further Understanding Mycobacterial Biofilms and Their Interaction with the Host

Creator:: Rose, Sasha J.
Abstract:: Respiratory infections caused by nontuberculous mycobacteria (NTM), especially Mycobacterium avium, can lead to progressive, recurrent disease that is refractory to therapy. Bacterial biofilms are intrinsically resistant to a variety of stressors and pressures, including host killing mechanisms and antibiotic therapy. Though it is becoming increasingly evident that NTM biofilms are...
Resource Type:: Dissertation
Full Text:: al. 2009; Falkinham 2011; Liu, Yu et al. 2012; Whiley, Keegan et al. 2012; Thomson, Tolson et al

Clostridium perfringens spores : inactivation, germination, and formation

Creator:: Udompijitkul, Pathima
Abstract:: The enterotoxin-producing Clostridium perfringens type A isolates are responsible for the third most common foodborne illness in the United States and can also cause non-foodborne human gastrointestinal (GI) diseases such as antibiotic- associated and sporadic diarrheas. Three important factors contribute to the ability of C. perfringens to cause GI diseases,...
Resource Type:: Dissertation
Full Text:: forespore. The successive event in stage V is the formation of the complex structure of proteins outside

Syntheses and evaluation of putative enzyme inhibitor of isoprenoid biosynthesis

Creator:: Phaosiri, Chanokporn
Abstract:: The discovery of the methylerythritol phosphate pathway (the MEP pathway) as an alternate pathway for isoprenoid biosynthesis in some organisms including most bacteria, malarial parasites and plants, but not in animals, has stimulated extensive studies in this area. Research has revealed the potential of finding novel antibacterials, antimalarial drugs, and...
Resource Type:: Dissertation
Full Text:: TLC Thin Layer Chromatography TPAP Tetrapropylammonium pemithenate tR Retention Time V volume

Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

Creator:: McNamara, Michael J.
Abstract:: Mycobacterium avium subsp. hominissuis (MAH) is a pervasive environmental bacterium that can cause opportunistic infections in humans. Among the most robust and hardy members of the Mycobacterium genus, M. avium can persist and thrive in a range of challenging environments, including many which place it in direct contact with humans....
Resource Type:: Dissertation

Investigation of unique marine environments for microbial natural products

Creator:: Thornburg, Christopher C.
Abstract:: Metagenomics has revealed that the marine microbial biosphere is immensely more diverse than originally considered, and is an almost untapped reservoir for the potential discovery of microbial natural products. Despite numerous advances in culturing, biosynthetic engineering and genomic-based screening efforts to uncover much of this diversity in relatively accessible environments,...
Resource Type:: Dissertation

Evolutionary Genomic Responses to Mitochondrial Dysfunction in Caenorhabditis elegans

Creator:: Wernick, Riana I.
Abstract:: Understanding the impact of mitochondrial dysfunction on genome evolution has the potential not only to provide new insights on the basic evolutionary processes influencing mitochondrial and nuclear genomes, but may also reveal novel avenues for evolutionary adaptive recovery from harmful mutations. Aberrant mitochondrial activity is fundamental to the pathology of...
Resource Type:: Dissertation
Full Text:: of five complexes (I-V) that couple the transfer of electrons with the pumping of protons (H+ ions

The role of chlamydial inclusion membrane proteins in host-pathogen interaction and the development of novel methods for studying chlamydial biology

Creator:: Alzhanov, Damir T.
Abstract:: The majority of our modern understanding of bacterial pathogenesis is based on the strategy that involves screening bacterial genomes for the presence of the genes encoding pathogenic factors, and analysis of these genes via forward and reverse genetics. Chlamydiae represent a unique group of pathogenic bacteria in which it is...
Resource Type:: Dissertation

Development of Novel Agents to Combat Tuberculosis and Malaria

Creator:: Almabruk, Khaled Husain G.
Abstract:: Despite the advance of biomedical science, infectious diseases remain one of the number one killers in the world. They claim the lives of millions of people annually, particularly in underdeveloped and developing countries. In fact, more than 32% of the health burden in Africa is caused by infectious diseases, e.g.,...
Resource Type:: Dissertation
Full Text:: Data…………………………………………………………..157 4.5 References……………………………………………………………………171 CHAPTER V: General

Structural studies of the antioxidant defense enzymes; copper, zinc superoxide dismutase and alkyl hydroperoxide reductase flavoprotein

Creator:: Roberts, Blaine R.
Abstract:: Oxygen derived radicals are involved in many aspects of life from aging and cell signaling to disease states as diverse as heart disease, diabetes, neurodegeneration and inflammation. Therefore, understanding the function of antioxidant defense proteins and the effects of oxygen derived radicals on protein function is essential to elucidate the...
Resource Type:: Dissertation

Characterization of an inhibitor ("6S") of infectious pancreatic necrosis virus (IPNV) in normal rainbow trout serum (RTS) and its effects on the virus

Creator:: Park, Kyoung Chul
Abstract:: The characteristics of an inhibitor of infectious pancreatic necrosis virus (IPNV) found in normal rainbow trout serum (RTS) were studied. The serum inhibitor had a molecular weight of approximately 150 kDa and was dependent on divalent cations, either Ca²⁺ or Mg²⁺. It was stable at temperatures up to 50°C and...
Resource Type:: Dissertation
Full Text:: ........................................................... 37 3.3 Distribution of inhibition activity of RTS against IPN V-Jasper after fractionation on

ScholarsArchive@OSU

Molecular and cellular characterization of the intracellular phenotype of Mycobacterium avium

Characterization of Mycobacterium avium subsp. hominissuis Interactions with Host Macrophages and Multinucleated Giant Cells

Biochemical Studies of Pactamycin Biosynthesis in Streptomyces pactum

The MAV_4644 dual-function channel protein with putative ADP-ribosyltransferase activity of Mycobacterium avium is required for virulence within host macrophages

Further Understanding Mycobacterial Biofilms and Their Interaction with the Host

Clostridium perfringens spores : inactivation, germination, and formation

Syntheses and evaluation of putative enzyme inhibitor of isoprenoid biosynthesis

Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

Investigation of unique marine environments for microbial natural products

Evolutionary Genomic Responses to Mitochondrial Dysfunction in Caenorhabditis elegans

The role of chlamydial inclusion membrane proteins in host-pathogen interaction and the development of novel methods for studying chlamydial biology

Development of Novel Agents to Combat Tuberculosis and Malaria

Structural studies of the antioxidant defense enzymes; copper, zinc superoxide dismutase and alkyl hydroperoxide reductase flavoprotein

Characterization of an inhibitor ("6S") of infectious pancreatic necrosis virus (IPNV) in normal rainbow trout serum (RTS) and its effects on the virus

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Creator

Contributor

Date

Decade

Degree Field

Degree Level

Degree Name

File Format

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search