Index Catalog // ScholarsArchive@OSU

Establishment of an in vitro System for Studying Mycobacterium avium Protein Secretion

Creator:: Chinison, Jessica J.
Abstract:: Cases of pulmonary diseases caused by Mycobacterium avium complex (MAC) have increased over the years and have become a major health concern in Europe, Asia, and the United States. MAC, comprised of M. avium species and M. intracellulare, are found everywhere in the environment: in water sources and the soil....
Resource Type:: Masters Thesis
Full Text:: for submission (1).docx AN ABSTRACT OF THE THESIS OF Jessica J. Chinison for the degree

Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

Creator:: McNamara, Michael J.
Abstract:: Mycobacterium avium subsp. hominissuis (MAH) is a pervasive environmental bacterium that can cause opportunistic infections in humans. Among the most robust and hardy members of the Mycobacterium genus, M. avium can persist and thrive in a range of challenging environments, including many which place it in direct contact with humans....
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Michael J

The role of chlamydial inclusion membrane proteins in host-pathogen interaction and the development of novel methods for studying chlamydial biology

Creator:: Alzhanov, Damir T.
Abstract:: The majority of our modern understanding of bacterial pathogenesis is based on the strategy that involves screening bacterial genomes for the presence of the genes encoding pathogenic factors, and analysis of these genes via forward and reverse genetics. Chlamydiae represent a unique group of pathogenic bacteria in which it is...
Resource Type:: Dissertation

The Inhibitory Activity of Essential Oil Constituents Against Clostridium perfringens Type A Isolates

Creator:: Alanazi, Saud
Abstract:: C. perfringens type A isolates are the causative agents of C. perfringens type A food poisoning (FP) and non-food-borne (NFB) human gastrointestinal diseases. In this study, we evaluated the antimicrobial effect of essential oil constituents (cinnamaldehyde, eugenol, allyl isothiocyanate (AITC), and carvacrol) against C. perfringens FP and NFB isolates grown...
Resource Type:: Masters Thesis
Full Text:: (Cha & Chinnan, 2004; Gutierrez, Barry-Ryan, & Bourke, 2008; Natrajan & Sheldon, 2000). In some cases

Development of Novel Agents to Combat Tuberculosis and Malaria

Creator:: Almabruk, Khaled Husain G.
Abstract:: Despite the advance of biomedical science, infectious diseases remain one of the number one killers in the world. They claim the lives of millions of people annually, particularly in underdeveloped and developing countries. In fact, more than 32% of the health burden in Africa is caused by infectious diseases, e.g.,...
Resource Type:: Dissertation

Characterization of microaggregate formation by Mycobacterium avium subspecies hominissuis

Creator:: Babrak, Lmar
Abstract:: Mycobacterium avium subsp hominissuis (MAH) is an opportunistic environmental pathogen that causes respiratory and gastrointestinal illness in immunocompromised persons such as those with chronic respiratory diseases or AIDs, respectively. In recent years, there has been a significant increase in the incidence of nontuberculous mycobacterial (NTM) lung infections, including in cystic...
Resource Type:: Dissertation

Molecular and cellular characterization of the intracellular phenotype of Mycobacterium avium

Creator:: Early, Julie V.
Abstract:: Mycobacterium avium cause disseminated disease in immunocompromised people such as AIDS patients. Subsequent to crossing the intestinal epithelium, M. avium thrive within vacuoles in macrophages. The bacteria exhibit a different, more invasive, phenotype after being in macrophages compared to M. avium from laboratory conditions. We hypothesized that this intracellular phenotype...
Resource Type:: Dissertation
Full Text:: . Infect Immun. 1983 Jun;40(3):1155-62. Bhattacharyya A, Pathak S, Basak C, Law S, Kundu M, Basu J

Inhibition of Clostridium perfringens spore growth by synergistic effects of different antimicrobials

Creator:: Alhabeeb, Rabiaa
Abstract:: Clostridium perfringens is a spore-forming anaerobic organism that is commonly present in fresh meat and poultry. The organism's spores can survive a range of food processing methods. C. perfringens type F isolates are the causative agents of C. perfringens type F food poisoning (FP) and non-food borne (NFB) human gastrointestinal...
Resource Type:: Masters Thesis
Full Text:: active site and an alpha- sandwich C-terminal domain that is responsible for membrane binding ((J

Mechanistic Studies and Catalytic Engineering of the Pseudoglycosyltransferase VldE

Creator:: Abuelizz, Hatem A.
Abstract:: This thesis describes an investigation of the molecular basis of the substrate specificity and catalytic mechanism of a unique pseudoglycosyltransferase (PsGT) enzyme, VldE. PsGTs are a newly discovered group of glycosyltransferase (GT)-like proteins that catalyze the transfer of a pseudosugar to an acceptor molecule via a C-N bond formation. This...
Resource Type:: Dissertation

Characterization of an inhibitor ("6S") of infectious pancreatic necrosis virus (IPNV) in normal rainbow trout serum (RTS) and its effects on the virus

Creator:: Park, Kyoung Chul
Abstract:: The characteristics of an inhibitor of infectious pancreatic necrosis virus (IPNV) found in normal rainbow trout serum (RTS) were studied. The serum inhibitor had a molecular weight of approximately 150 kDa and was dependent on divalent cations, either Ca²⁺ or Mg²⁺. It was stable at temperatures up to 50°C and...
Resource Type:: Dissertation

ScholarsArchive@OSU

Establishment of an in vitro System for Studying Mycobacterium avium Protein Secretion

Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

The role of chlamydial inclusion membrane proteins in host-pathogen interaction and the development of novel methods for studying chlamydial biology

The Inhibitory Activity of Essential Oil Constituents Against Clostridium perfringens Type A Isolates

Development of Novel Agents to Combat Tuberculosis and Malaria

Characterization of microaggregate formation by Mycobacterium avium subspecies hominissuis

Molecular and cellular characterization of the intracellular phenotype of Mycobacterium avium

Inhibition of Clostridium perfringens spore growth by synergistic effects of different antimicrobials

Mechanistic Studies and Catalytic Engineering of the Pseudoglycosyltransferase VldE

Characterization of an inhibitor ("6S") of infectious pancreatic necrosis virus (IPNV) in normal rainbow trout serum (RTS) and its effects on the virus

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