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Filtering by: Alternative title ssim 4-H 6401 Remove constraint Alternative title ssim: 4-H 6401 Committee Member Rohrmann, George Remove constraint Committee Member: Rohrmann, George

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  • Fatty acylation of Vaccinia virus proteins : dual myristylation and palmitylation of the A-type inclusion protein

    Creator:
    Martin, Karen H.
    Abstract:
    The attachment of myristic acid to the N-terminal glycine residue of many eukaryotic and viral proteins is often essential for the acquisition of the protein's biological activity. Vaccinia virus (VV), the prototype member of the Poxviridae, expresses several myristylated proteins during the course of infection. Only one of these proteins,...
    Resource Type:
    Dissertation
    Full Text:
    4 ml with hypotonic buffer and centrifuged at 33,000 rpm for 1 h at 4°C. The pellet (P100) was

  • Palmitylation of vaccinia virus proteins : identification of modification sites and biological relevance

    Creator:
    Grosenbach, Douglas W.
    Abstract:
    Vaccinia virus encodes at least eight proteins that are modified post-translationally by the addition of a 16-carbon saturated fatty acid through thioester linkage to cysteine residues. This is referred to as palmitylation of proteins. The purpose of this work was to gain an understanding of palmitylation, focusing on what defined...
    Resource Type:
    Dissertation
    Full Text:
    1.3.2 Palmitylproteins .................................................................20 1 .4

  • Identification and analysis of vaccinia virus acylproteins

    Creator:
    Hansen, Scott G.
    Abstract:
    Vaccinia virus (VV) encodes at least six proteins that are modified by the addition of a 14-carbon saturated fatty acid through an amide linkage and at least eight proteins that are modified post-translationally by the addition of a 16-carbon saturated fatty acid through linkage to cysteine residues. These post-translational modifications...
    Resource Type:
    Dissertation
    Full Text:
    % of the protein-bound myristate was rapidly (<4 h) elongated to palmitate in these cells, and the