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Filtering by: Creator Berman, T. Committee Member Schimerlik, Michael Degree Field Biochemistry and Biophysics

Characterization of the mechanism and function of C₂H₂ zinc finger protein CTIP2 in the developmental processes

Creator:

Golonzhka, Olga

Abstract:

CTIP2 is a C2H2 zinc finger transcription factor that plays important yet poorly understood roles in mouse development. CTIP2 is known to be highly expressed in the central nervous system, skin and T lymphocytes during embryogenesis. CTIP2-null mice die perinatally of unknown causes and exhibit defects in multiple organ systems...

Resource Type:

Dissertation

Full Text:

, skin and T lymphocytes during embryogenesis. CTIP2-null mice die perinatally of unknown causes and
The asymmetric binding of Actinomycin D to DNA hexamers

Creator:

Ivancic, Monika

Abstract:

The solution structure determination of DNA molecules has been an important part of structural biology. NMR solution structures are a complement to structures solved via X-ray crystallography; the two methods are the only ways of obtaining three dimensional coordinates of macromolecules. Because of the nature of the molecule, the solution...

Resource Type:

Dissertation
Structural studies of the antioxidant defense enzymes; copper, zinc superoxide dismutase and alkyl hydroperoxide reductase flavoprotein

Creator:

Roberts, Blaine R.

Abstract:

Oxygen derived radicals are involved in many aspects of life from aging and cell signaling to disease states as diverse as heart disease, diabetes, neurodegeneration and inflammation. Therefore, understanding the function of antioxidant defense proteins and the effects of oxygen derived radicals on protein function is essential to elucidate the...

Resource Type:

Dissertation