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Filtering by: Creator Berman, T. Committee Member Schimerlik, Michael Degree Name Master of Science (M.S.)

Effects of quinolinate and nitro-, or thio- substituted analogs of quinolinate on glutamate receptor-mediated neurotoxicity in cerebellar granule cell cultures

Creator:

Zhang, Jinying

Abstract:

Quinolinate (QUIN) is an endogenous neurotoxic product of the kynurenine pathway of tryptophan metabolism. Quinolinate is a selective agonist of the NMDA family of glutamate receptors and, as such, may play a role in the pathology of a number of major central nervous system (CNS) disorders. These include both chronic...

Resource Type:

Masters Thesis

Full Text:

(Goldberg et al., 1987; Shalaby et al., 1989; Priestley, 1990; Berman and Murray, 1996). We chose