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Filtering by: Creator Berman, T. Remove constraint Creator: Berman, T. Committee Member Schimerlik, Michael Remove constraint Committee Member: Schimerlik, Michael Resource Type Dissertation Remove constraint Resource Type: Dissertation

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Characterization of the mechanism and function of C₂H₂ zinc finger protein CTIP2 in the developmental processes

Creator:

Golonzhka, Olga

Abstract:

CTIP2 is a C2H2 zinc finger transcription factor that plays important yet poorly understood roles in mouse development. CTIP2 is known to be highly expressed in the central nervous system, skin and T lymphocytes during embryogenesis. CTIP2-null mice die perinatally of unknown causes and exhibit defects in multiple organ systems...

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Dissertation

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, skin and T lymphocytes during embryogenesis. CTIP2-null mice die perinatally of unknown causes and
Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

Creator:

Han, Bingnan

Abstract:

This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of eighteen new secondary metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D NMR data, respectively. Preliminary bioassays of the crude...

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Dissertation

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-, monohydrochloride t Triplet TEA Trifluoroacetic acid TOCSY Total Correlation Spectroscopy tR Retention Time Tyr
The asymmetric binding of Actinomycin D to DNA hexamers

Creator:

Ivancic, Monika

Abstract:

The solution structure determination of DNA molecules has been an important part of structural biology. NMR solution structures are a complement to structures solved via X-ray crystallography; the two methods are the only ways of obtaining three dimensional coordinates of macromolecules. Because of the nature of the molecule, the solution...

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Dissertation
Structural studies of the antioxidant defense enzymes; copper, zinc superoxide dismutase and alkyl hydroperoxide reductase flavoprotein

Creator:

Roberts, Blaine R.

Abstract:

Oxygen derived radicals are involved in many aspects of life from aging and cell signaling to disease states as diverse as heart disease, diabetes, neurodegeneration and inflammation. Therefore, understanding the function of antioxidant defense proteins and the effects of oxygen derived radicals on protein function is essential to elucidate the...

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Dissertation

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Academic Affiliation

Biochemistry and Biophysics3
College of Pharmacy1

Advisor

Beckman, Joseph1
Gerwick, William H.1
Hsu, Victor L.1
Leid, Mark1

Commencement Year

Commencement Year range begin – Commencement Year range end

Current results range from 2002 to 2009

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Committee Member

Schimerlik, Michael[remove]4
Coblentz, Bruce1
Constantine, George1
Deinzer, Max1
Karplus, Andrew1
more Committee Members »

Creator

Golonzhka, Olga1
Han, Bingnan1
Ivancic, Monika1
Roberts, Blaine R.1

Date

Date range begin – Date range end

Current results range from 2001 to 2008

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Decade

2000-20094

Degree Field

Biochemistry and Biophysics3
Pharmacy1

Degree Level

Doctoral4

Degree Name

Doctor of Philosophy (Ph.D.)4

File Format

application/pdf1

Language

English [eng]4

License

All rights reserved2

Non-Academic Affiliation

Oregon State University. Graduate School4

Peer Reviewed

No4

Resource Type

Dissertation[remove]4

Rights Statement

Copyright Not Evaluated2
In Copyright2

Subject

Actinomycin1
Antineoplastic agents1
DNA-drug interactions1
Developmental biology1
Genetic transcription -- Regulation1
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