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Creator:: Golonzhka, Olga
Abstract:: CTIP2 is a C2H2 zinc finger transcription factor that plays important yet poorly understood roles in mouse development. CTIP2 is known to be highly expressed in the central nervous system, skin and T lymphocytes during embryogenesis. CTIP2-null mice die perinatally of unknown causes and exhibit defects in multiple organ systems...
Resource Type:: Dissertation
Full Text:: Characterization of the Mechanism and Function of C2H2 Zinc Finger Protein CTIP2 in the Developmental Processes

Creator:: Hsu, Cheng-kuang
Resource Type:: Masters Thesis
Full Text:: Physical, Thermal and Chemical Methods to Measure Protein Denaturation in Frozen Pacific Whiting

Creator:: Hooven, Louisa Ada
Abstract:: Exposure to polycyclic aromatic hydrocarbons such as benzo[a]pyrene (B[a]P) has been determined to be a risk factor for various forms of human cancer. PAH DNA adducts have been shown to cause mutations, but carcinogenesis is also accompanied by alterations in gene expression. Inhibiting individual cytochrome P450s could clarify the interaction...
Resource Type:: Dissertation
Full Text:: global protein expression changes after treatment with PAR, MCF-7 cells were treated with B[aJP, DB{a

Creator:: Doneanu, Catalin E.
Abstract:: The DNA-binding domains of E. coli uracil-DNA glycosylase (Ung) and human replication protein A (hRPA) were studied using a general protocol developed in our laboratory for probing protein-DNA interactions. The procedure involves purification and mass spectrometric analysis of the nucleopeptide-products of a tryptically digested UV-crosslinked protein-nucleic acid complex. In the...
Resource Type:: Dissertation
Full Text:: Analysis of UV- Crosslinked Protein-Nucleic Acid Complexes Abstract approved: F. Barofsky The DNA

Creator:: Roberts, Blaine R.
Abstract:: Oxygen derived radicals are involved in many aspects of life from aging and cell signaling to disease states as diverse as heart disease, diabetes, neurodegeneration and inflammation. Therefore, understanding the function of antioxidant defense proteins and the effects of oxygen derived radicals on protein function is essential to elucidate the...
Resource Type:: Dissertation
Full Text:: function of antioxidant defense proteins and the effects of oxygen derived radicals on protein function

Creator:: Topark-Ngarm, Acharawan Khamsiritrakul
Abstract:: CTIP2, a novel C2H2 zinc finger protein, is a transcriptional repressor that functions by at least two mechanisms. CTIP2 interacts with and stimulates transcriptional repression mediated by COUP-TF family members. CTIP2 also represses transcription independently of COUP-TF proteins by direct, sequence-specific DNA binding activity. CTIP2 has been implicated in lymphoid...
Resource Type:: Dissertation
Full Text:: Protein. Abstract approved: Mark E. Leid CTIP2, a novel C2H2 zinc finger protein

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