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Filtering by: Committee Member Siddens, Lisbeth K. Date 2016 Degree Name Honors Bachelor of Science (H.B.S.) Rights Statement In Copyright

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Creator:

You, Hyekyoung Hannah

Abstract:

Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...

Resource Type:

Honors College Thesis