Index Catalog // ScholarsArchive@OSU

Automated manipulation of zebrafish embryos for high-throughput toxicology screening of nanomaterials

Creator:: Mandrell, David
Abstract:: The field of nanotechnology has been rapidly developing new materials. These materials have become incorporated into consumer products and the environment after only minimal assessment of their effects on human health or the environment. The toxicity of these new nanomaterials remains unknown due to the unpredictable nature of the core...
Resource Type:: Masters Thesis
Full Text:: to thank Dr. Robert Tanguay for giving me the opportunity to work on a project that I have truly

Exposure to the Mycotoxin Zearalenone Impairs Embryonic Development in Zebrafish

Creator:: Sidebotham, Nicole A.
Abstract:: A study was conducted to evaluate the developmental toxicity of three commonly detected mycotoxins in food (deoxynivalenol, patulin, and zearalenone) using the zebrafish (Danio rerio) model. Mycotoxin exposures were carried out at five concentrations (0.0064, 0.064, 0.64, 6.4, and 64 μM). Morphological and photomotor screenings were conducted at 24 hours...
Resource Type:: Honors College Thesis
Full Text:: Robert Tanguay, Committee Member, representing the Department of Environmental and Molecular Toxicology

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Creator:: Madeen, Erin
Abstract:: The objective of this work is to add to the body of translational data between high dose animal model research and the environmentally relevant human metabolism of the persistent pollutant dibenzo[def,p]chrysene (DBC). We furthered the knowledge of gene/exposure interactions by determining the carcinogenesis risk based on Cyp1b1 genotype following in...
Resource Type:: Dissertation
Full Text:: and Susan Crowell provided training and advice on pharmacokinetic analysis. Kenneth Turteltaub, Ted

Analysis of Cancer Progression by Establishing Quantitative Assessments of Zebrafish Xenografts

Creator:: Gamble, John T.
Abstract:: The goal of this dissertation was to improve our abilities in acquiring critical in vivo data by establishing embryo-larva zebrafish as an exemplary model to quantitatively evaluate cancer progression. The living environment that encompasses a tumor has a significant effect on how cancer develops, grows and metastasizes. In order to...
Resource Type:: Dissertation
Full Text:: needed zebrafish last minute. Also, I cannot forget to thank Robert Tanguay for his advice and help

Characterization of the mechanism and function of C₂H₂ zinc finger protein CTIP2 in the developmental processes

Creator:: Golonzhka, Olga
Abstract:: CTIP2 is a C2H2 zinc finger transcription factor that plays important yet poorly understood roles in mouse development. CTIP2 is known to be highly expressed in the central nervous system, skin and T lymphocytes during embryogenesis. CTIP2-null mice die perinatally of unknown causes and exhibit defects in multiple organ systems...
Resource Type:: Dissertation

Assessment of the neuropathological consequences of vitamin E deficiency

Creator:: McDougall, Melissa Quin
Abstract:: Cognitive impairment, or cognitive decline, a noticeable and measurable decline in cognitive abilities (e.g. memory and learning) that exceeds those attributed to normal aging, represents an early symptom of neurodegeneration and increased risk for progression to more severe dementias, such as Alzheimer's disease (AD). While the complex etiology of these...
Resource Type:: Dissertation
Full Text:: of my doctoral committee, Drs. Donald Jump, Kathy Magnusson, Robert Tanguay, and Theresa Filtz

Investigations of regulatory T cell induction by 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin during a graft-versus-host response

Creator:: Marshall, Nikki B.
Abstract:: The immune toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been studied for over 35 years, but only recently has the profound immune suppression associated with TCDD exposure been linked to induction of regulatory T cells (Tregs). The effects of TCDD are mediated through binding the aryl hydrocarbon receptor (AhR), a ligand-activated transcription...
Resource Type:: Dissertation

New applications and emerging contaminants : developing silicone passive sampling devices for environmental and novel monitoring applications

Creator:: O'Connell, Steven G.
Abstract:: Passive sampling is a popular technology for environmental monitoring, and silicone is an ideal choice for a variety of passive sampling applications. The silicone work described here encompasses laboratory and field studies that demonstrate the use of this polymer in novel environments, for new applications, and for emerging compounds. Unique...
Resource Type:: Dissertation
Full Text:: like to express gratitude to my graduate committee: Drs. Robert Tanguay, Joe Beckman, Dixon Landers

Pseudoloma neurophilia : progression of infection and transmission characteristics of a microsporidian parasite in a model vertebrate, Danio rerio

Creator:: Sanders, Justin L.
Abstract:: The microsporidian parasite, Pseudoloma neurophilia, is the most commonly diagnosed infectious disease in laboratory populations of the zebrafish, Danio rerio. Infections by P. neurophilia are generally subclinical, however, they can become acute either incidentally or due to experimental immune suppression. Non-protocol induced variation can confound results in laboratory experiments using...
Resource Type:: Dissertation
Full Text:: . Luiz Bermudez, Kathy O'Reilly, Michelle Steinauer, and Robert Tanguay, for their guidance, advice

Roles for retinoid-X-receptors in solar UV-induced melanocyte homeostasis and melanomagenesis

Creator:: Coleman, Daniel J.
Abstract:: Melanoma is the deadliest form of skin cancer, arising from malignant transformation of pigment-producing melanocytes. The primary risk factor for melanoma and other skin cancers is DNA damage resulting from unprotected solar ultraviolet radiation (UVR). If incorrectly repaired, this damage can result in incorporation of mutations that cause aberrant cell...
Resource Type:: Dissertation

ScholarsArchive@OSU

Automated manipulation of zebrafish embryos for high-throughput toxicology screening of nanomaterials

Exposure to the Mycotoxin Zearalenone Impairs Embryonic Development in Zebrafish

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Analysis of Cancer Progression by Establishing Quantitative Assessments of Zebrafish Xenografts

Characterization of the mechanism and function of C₂H₂ zinc finger protein CTIP2 in the developmental processes

Assessment of the neuropathological consequences of vitamin E deficiency

Investigations of regulatory T cell induction by 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin during a graft-versus-host response

New applications and emerging contaminants : developing silicone passive sampling devices for environmental and novel monitoring applications

Pseudoloma neurophilia : progression of infection and transmission characteristics of a microsporidian parasite in a model vertebrate, Danio rerio

Roles for retinoid-X-receptors in solar UV-induced melanocyte homeostasis and melanomagenesis

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