Index Catalog // ScholarsArchive@OSU

The use of natural plant extracts as a feed additive to prevent laminitis in lactating dairy cows

Creator:: Pierson, Miranda L.
Abstract:: Two experiments were conducted looking at both acute and sub-acute laminitis. An acute nutritional induction model was used to examine whether blood profiles and gene expression are similar to other studies conducted using an endotoxin induction model. Twelve sheep were randomly assigned to three treatment groups which were control, 4-hour...
Resource Type:: Masters Thesis
Full Text:: Mike Gamroth and Dr. Robert Tanguay for joining my graduate committee on such short notice. I would

Exposure to the Mycotoxin Zearalenone Impairs Embryonic Development in Zebrafish

Creator:: Sidebotham, Nicole A.
Abstract:: A study was conducted to evaluate the developmental toxicity of three commonly detected mycotoxins in food (deoxynivalenol, patulin, and zearalenone) using the zebrafish (Danio rerio) model. Mycotoxin exposures were carried out at five concentrations (0.0064, 0.064, 0.64, 6.4, and 64 μM). Morphological and photomotor screenings were conducted at 24 hours...
Resource Type:: Honors College Thesis
Full Text:: Robert Tanguay, Committee Member, representing the Department of Environmental and Molecular Toxicology

Analysis of Cancer Progression by Establishing Quantitative Assessments of Zebrafish Xenografts

Creator:: Gamble, John T.
Abstract:: The goal of this dissertation was to improve our abilities in acquiring critical in vivo data by establishing embryo-larva zebrafish as an exemplary model to quantitatively evaluate cancer progression. The living environment that encompasses a tumor has a significant effect on how cancer develops, grows and metastasizes. In order to...
Resource Type:: Dissertation
Full Text:: needed zebrafish last minute. Also, I cannot forget to thank Robert Tanguay for his advice and help

Pseudoloma neurophilia : progression of infection and transmission characteristics of a microsporidian parasite in a model vertebrate, Danio rerio

Creator:: Sanders, Justin L.
Abstract:: The microsporidian parasite, Pseudoloma neurophilia, is the most commonly diagnosed infectious disease in laboratory populations of the zebrafish, Danio rerio. Infections by P. neurophilia are generally subclinical, however, they can become acute either incidentally or due to experimental immune suppression. Non-protocol induced variation can confound results in laboratory experiments using...
Resource Type:: Dissertation
Full Text:: . Luiz Bermudez, Kathy O'Reilly, Michelle Steinauer, and Robert Tanguay, for their guidance, advice

New applications and emerging contaminants : developing silicone passive sampling devices for environmental and novel monitoring applications

Creator:: O'Connell, Steven G.
Abstract:: Passive sampling is a popular technology for environmental monitoring, and silicone is an ideal choice for a variety of passive sampling applications. The silicone work described here encompasses laboratory and field studies that demonstrate the use of this polymer in novel environments, for new applications, and for emerging compounds. Unique...
Resource Type:: Dissertation
Full Text:: like to express gratitude to my graduate committee: Drs. Robert Tanguay, Joe Beckman, Dixon Landers

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Creator:: Larsen, Christine A.
Abstract:: Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
Resource Type:: Dissertation
Full Text:: also like to show my appreciation for my committee members, Dr. Emily Ho, Dr. Robert Tanguay, Dr

Assessment of the neuropathological consequences of vitamin E deficiency

Creator:: McDougall, Melissa Quin
Abstract:: Cognitive impairment, or cognitive decline, a noticeable and measurable decline in cognitive abilities (e.g. memory and learning) that exceeds those attributed to normal aging, represents an early symptom of neurodegeneration and increased risk for progression to more severe dementias, such as Alzheimer's disease (AD). While the complex etiology of these...
Resource Type:: Dissertation
Full Text:: of my doctoral committee, Drs. Donald Jump, Kathy Magnusson, Robert Tanguay, and Theresa Filtz

Mass spectrometry techniques to assess the metabolism and toxicity of pharmaceutical and dietary nitrates

Creator:: Axton, Elizabeth R.
Abstract:: Nitric oxide (NO) is a signaling molecule that regulates blood pressure and vascular tone. Humans produce NO by endothelial nitric oxide synthase (eNOS), which is impaired in patients with cardiovascular disease leading to increased blood pressure, endothelial dysfunction, and an increased risk of adverse cardiovascular outcomes. Maintaining optimal levels of...
Resource Type:: Dissertation
Full Text:: : ____________________________________________________ Jan F. Stevens and Robert Tanguay Nitric oxide (NO) is a signaling molecule that regulates

Advances in Passive Sampling : Measuring Chemical Transport and Human Exposures

Creator:: Donald, Carey E.
Abstract:: Passive sampling devices have been used for decades to measure complex mixtures of bioavailable organic chemicals in a variety of environmental media. More recently passive sampler applications have expanded beyond monitoring chemical concentrations, and this dissertation continues to advance methods of passive sampling on many fronts. Despite their growing use,...
Resource Type:: Dissertation
Full Text:: committee, Dr. Robert Tanguay, Dr. Staci Simonich, Dr. Jennifer Field, and Dr. Molly Kile, for guidance

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Creator:: Madeen, Erin
Abstract:: The objective of this work is to add to the body of translational data between high dose animal model research and the environmentally relevant human metabolism of the persistent pollutant dibenzo[def,p]chrysene (DBC). We furthered the knowledge of gene/exposure interactions by determining the carcinogenesis risk based on Cyp1b1 genotype following in...
Resource Type:: Dissertation

ScholarsArchive@OSU

The use of natural plant extracts as a feed additive to prevent laminitis in lactating dairy cows

Exposure to the Mycotoxin Zearalenone Impairs Embryonic Development in Zebrafish

Analysis of Cancer Progression by Establishing Quantitative Assessments of Zebrafish Xenografts

Pseudoloma neurophilia : progression of infection and transmission characteristics of a microsporidian parasite in a model vertebrate, Danio rerio

New applications and emerging contaminants : developing silicone passive sampling devices for environmental and novel monitoring applications

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Assessment of the neuropathological consequences of vitamin E deficiency

Mass spectrometry techniques to assess the metabolism and toxicity of pharmaceutical and dietary nitrates

Advances in Passive Sampling : Measuring Chemical Transport and Human Exposures

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

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