Index Catalog // ScholarsArchive@OSU

Genomics-enabled exploration of insect toxicity in the Pseudomonas fluorescens group

Creator:: Rangel, Lorena I.
Abstract:: Pseudomonas is a diverse genus of Gamma proteobacteria that are ubiquitous in the natural environment, including soil, water, plant surfaces, and animals. The Pseudomonas fluorescens group is a diverse collection of seven subgroups and more than 50 named species. This group is known for their production of a variety of...
Resource Type:: Masters Thesis
Full Text:: function of the Manatee program (J. Craig Venter Institute, Gaithersburg, Maryland). Tc genes present in

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Creator:: Garcia, Gloria R.
Abstract:: The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is a member of the basic helix-loop-helix PER-ARNT-SIM (bHLH/PAS) protein family of cellular sensors. The AHR is conserved across multiple animal phyla and is required for proper vertebrate development. A structurally diverse group of chemicals, including polycyclic aromatic...
Resource Type:: Dissertation

Functional and Structural Analyses of Three Distinct proteins by Biochemical and Biophysical Techniques

Creator:: Codding, Sara Jone
Abstract:: The focus of this dissertation was to understand protein function and structure ona molecular level. To do this successfully, a variety of biochemical and biophysicaltechniques were employed. A wide variety of techniques were applied to study theproteins of interest in this dissertation to probe protein-protein interactions, proteinfunction, protein structure, and...
Resource Type:: Dissertation
Full Text:: Padmanarayana for our friendly conversations, and Naomi J. Marty, for always reminding me that life is short

Protein Disorder in the Evolution of Dynein Regulation

Creator:: Jie, Jing
Abstract:: Intrinsically disordered proteins (IDP) are a class of proteins that lack a three-dimensional structure and their prevalence and diverse functions in the cell have only been discovered relatively recently. The intermediate chain (IC) subunit of the microtubule motor protein complex dynein contains an N-terminal disordered region, N-IC, which is central...
Resource Type:: Dissertation
Full Text:: : _____________________________________________________ Elisar J. Barbar Intrinsically disordered proteins (IDP) are a class of proteins that lack

Identification of the plasminogen activator inhibitor produced by the day 14 bovine embryo

Creator:: Mendoza, Ruben
Abstract:: Day 12-14 bovine embryos produce urokinase-type plasminogen activator (uPA) and an uPA-plasminogen activator inhibitor (PAI) complex. The type of PAI, -1 or -2, in the complex has not been determined therefore the objective of this research was to identify the PAI produced by the Day 14 bovine embryo. In experiment...
Resource Type:: Masters Thesis

Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

Creator:: Baker, Kasie J.
Abstract:: The Hippo signaling pathway is an evolutionarily conserved regulator of cell growth, proliferation, and apoptosis. A key function of the pathway is to regulate the subcellular distribution and activity of Yorkie in Drosophila or Yes-associated protein (YAP) and transcription co-activator with PDZ-binding motif (TAZ) in mammals. The dysregulation of the...
Resource Type:: Dissertation
Full Text:: THE DISSERTATION OF Kasie J. Baker for the degree of Doctor of Philosophy in Biochemistry and

Toxicogenomic Biomarkers Associated with PAH Carcinogenic Potential in a 3D in Vitro Bronchial Epithelial Model

Creator:: Chang, Yvonne
Abstract:: The environmental health science community recognizes polycyclic aromatic hydrocarbons (PAHs) as a re-emerging class of environmental pollutants due to their persistence and prominence in mixtures of concern. Due to their widespread distribution in the environment, exposure to PAHs often occur as complex chemical mixtures. Exposures are linked to numerous adverse...
Resource Type:: Dissertation
Full Text:: . Staci Simonich, Dr. David Williams, Dr. Barbara Taylor, and Dr. Molly Megraw for their contributions

Investigating connections between the circadian system and aging in Drosophila melanogaster

Creator:: Long, Dani M.
Abstract:: Circadian clocks coordinate molecular, cellular, physiological, and behavioral processes with the 24-hour solar day. While clock functions are well understood in young animals, it is not clear how aging or neurodegenerative disease affects the various levels of the circadian system. A common symptom of many neurodegenerative diseases including Alzheimer’s disease...
Resource Type:: Dissertation

Homeodomain Transcription Factor Pitx2 is Required for Muscle Maintenance and Energy Homeostasis

Creator:: Lattier, Vera C.
Abstract:: Skeletal muscle, the largest organ in the body in mass, is composed by 600 specialized muscles in humans with unique biochemical, physiological and metabolic identities. Skeletal muscles control body movement, locomotion, and nutrient balance. Muscle formation requires precisely orchestrated environmental signals and regulatory gene networks in time and space. Gene...
Resource Type:: Dissertation
Full Text:: this far without her. I thank my committee member Dr. Barbara Taylor, Dr. Fred Stevens, Dr. Mark

Characterization of the Structure and Dynamics of the Intrinsically Disordered Dynein Intermediate Chain and its Interactions with Regulatory Binding Partners

Creator:: Morgan, Jessica L.
Abstract:: Cells represent microcosms of spatial and temporal structural organization, with the achievement of internal spatial organization relying upon a collection of macromolecular motor complexes to transport and localize components throughout the cell. Cytoplasmic dynein is one such motor complex, and is the principal ATP-dependent motor for retrograde transport along microtubules...
Resource Type:: Dissertation
Full Text:: Binding Partners. Abstract approved: ______________________________________________________ Elisar J

ScholarsArchive@OSU

Genomics-enabled exploration of insect toxicity in the Pseudomonas fluorescens group

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Functional and Structural Analyses of Three Distinct proteins by Biochemical and Biophysical Techniques

Protein Disorder in the Evolution of Dynein Regulation

Identification of the plasminogen activator inhibitor produced by the day 14 bovine embryo

Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

Toxicogenomic Biomarkers Associated with PAH Carcinogenic Potential in a 3D in Vitro Bronchial Epithelial Model

Investigating connections between the circadian system and aging in Drosophila melanogaster

Homeodomain Transcription Factor Pitx2 is Required for Muscle Maintenance and Energy Homeostasis

Characterization of the Structure and Dynamics of the Intrinsically Disordered Dynein Intermediate Chain and its Interactions with Regulatory Binding Partners

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