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Filtering by: Creator Merrill, Dawn C. Committee Member Turner, Russell Degree Level Bachelor's

Effects of Spaceflight on Cancellous and Cortical Bone in Proximal Femur in Rats

Creator:

Gamboa, Amanda R.

Abstract:

Bone loss is common in astronauts during long-duration spaceflight missions with severe bone loss often occurring in the proximal femur, a region not typically investigated in animal models for microgravity. We recently evaluated bone microarchitecture in the femoral head in rapidly growing male Sprague Dawley rats subjected to a 4-day...

Resource Type:

Honors College Thesis

Full Text:

Sciences _____________________________________________________________________ Dawn Olson, Committee
Hypothalamic Leptin Gene Therapy Does Not Prevent Ovariectomy-Induced Bone Loss in Rats

Creator:

Jackson, Melanie A.

Abstract:

Post-menopausal women are at an increased risk for osteoporosis due to increased bone resorption associated with estrogen deficiency. Subcutaneous administration of leptin, a hormone produced primarily by adipocytes, attenuates bone loss in the ovariectomized (ovx) rat, an animal model for post-menopausal bone loss. Leptin has both direct peripheral and indirect...

Resource Type:

Honors College Thesis

Full Text:

lined with osteoclasts, (B) cancellous bone perimeter lined with osteoblasts, (C) adipocyte density
Effects of Estrogen Receptor Blockade on Skeletal Response to Alcohol in Ovariectomized Rats

Creator:

Wagner, Lindsay A.

Abstract:

Heavy alcohol consumption reduces peak bone mass in growing rodents and can lead to bone loss in both adult rats and humans. In contrast, moderate alcohol consumption appears to have a bone sparing effect in post-menopausal women. Alcohol has been reported to increase aromatase activity and influence estrogen receptor (ER)...

Resource Type:

Honors College Thesis

Full Text:

alcohol and ICI 182,780 on tibia (A) length, (B) bone area, (C) bone mineral content, and (D) bone