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  • The role of leptin in normal and pathological bone resorption

    Creator:
    Philbrick, Kenneth Alan
    Abstract:
    Particles generated from wear of prosthesis joint bearing surfaces induce inflammation and promote pathological periprosthetic osteoclast-mediated bone resorption (osteolysis). Obesity increases the risk of prosthesis failure. However, despite being morbidly obese, leptin-deficient ob/ob mice are resistant to osteolysis. These findings suggest that leptin exerts effects that act to increase particle-induced...
    Resource Type:
    Dissertation
    Full Text:
    .......................................................................................................................... 14 Study 2.2: Effect of housing temperature on particle-induced osteolysis in WT Study 2.3

  • Examining the Effects of High Vitamin E Diets on the Rodent Skeleton

    Creator:
    Kasper, Katherine G.
    Abstract:
    The primary goal of my study was to evaluate the effects of high dietary vitamin E on the rodent skeleton. The outcomes from my study assess the impact of high intakes of vitamin E and increased concentrations of its metabolite, carboxy ethyl hydroxy chromanol (CEHC), on bone turnover and skeletal...
    Resource Type:
    Masters Thesis
    Full Text:
    with low serum osteocalcin; however, the physiological significance of this relationship is unclear

  • Dose response of zebrafish exposed to gamma radiation

    Creator:
    Haskins, Hillary Kate Marlane
    Abstract:
    Space radiation biology is an emerging field of research with a focus on improving the health and safety of astronauts in low-Earth orbit (LEO) and deep-space missions. Eye health is especially important to astronaut functionality. Recent studies have found an increased risk of cataract formation in astronauts with higher lens...
    Resource Type:
    Masters Thesis
    Full Text:
    damage. Cataract formation is a well-known effect of ionizing radiation exposure. It was once

  • DHA and Low-fat Low-cholesterol Diets as Treatment Strategies for Nonalcoholic Fatty Liver Disease

    Creator:
    Lytle, Kelli Anne
    Abstract:
    Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of excess neutral lipids within the parenchymal cells of the liver. The primary etiology is diet-induced and most often exists as a comorbidity with obesity, metabolic syndrome, and/or Type 2 Diabetes. The development of excess liver lipid can be self-limiting...
    Resource Type:
    Dissertation
    Full Text:
    key findings from this paper were that while DHA had little to no effect on circulating endocrine