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Filtering by: Creator Robinson, David Remove constraint Creator: Robinson, David Committee Member Williams, David Remove constraint Committee Member: Williams, David Creator Myzak, Melinda C. Remove constraint Creator: Myzak, Melinda C.

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  • A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

    Creator:
    Myzak, Melinda C.
    Abstract:
    Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...
    Resource Type:
    Dissertation
    Full Text:
    Leid, and David Williams, offered constructive suggestions and insight, as well as their time. I