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Filtering by: Creator Spitz, Yvette H. Committee Member Williams, David Decade 2000-2009

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Creator:

Myzak, Melinda C.

Abstract:

Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...

Resource Type:

Dissertation

Full Text:

approved: Roderick H. Dashwood Emily Targeting the epigenome, including the use of histone deacetylase
A proteomic approach to 1,2-dichloroethane bioactivation and reaction with redox-active protein disulfide isomerase

Creator:

Kaetzel, Rhonda Sue

Abstract:

Protein disulfide isomerase (PDI), a member of the thioredoxin superfamily, contains two domains with significant sequence homology to the active sites in thioredoxin. PDI facilitates the folding of nascent proteins in the endoplasmic reticulum (ER), binds hormones and Ca²⁺, catalyzes the glutathione dependent reduction of dehydroascorbate, serves as a major...

Resource Type:

Dissertation

Full Text:

4.11 MALDI-TOF/TOF Tandem Mass Spectra of the 117 [M+H] of the P4 Peptide (YAPWCGHCKALAPEY) Identifying