Index Catalog // ScholarsArchive@OSU

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

Creator:: Grochowski, Laura L.
Abstract:: Molecular genetic and enzymological techniques have been employed to study secondary metabolite biosynthesis. These investigations have focused on two projects: the cloning and heterologous expression of biosynthetic gene clusters from unculturable marine organisms and the characterization of individual enzymes involved in the biosynthesis of the antifungal agent blasticidin S. The...
Resource Type:: Dissertation
Full Text:: Enzymology of Secondary Metabolite Biosynthesis: I. Isolation of Natural Product Biosynthesis Gene Clusters

The mechanism of interaction of the linker histone with DNA and nucleosomes

Creator:: Ellen, Thomas Patrick
Abstract:: This dissertation examines the interaction of the linker histone with DNA and with nucleosomes. The first goal of the project was to characterize the interaction of the linker histone with DNA. Three factors previously reported to influence the linker histone's interaction with DNA were examined: ratio of linker histone to...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Thomas Patrick Ellen for the

The effects of environmental stressors on cardiac gene expression and contractility in rainbow trout (Oncorhynchus mykiss)

Creator:: Momoda, Tracey S.
Abstract:: Rainbow trout (Oncorhynchus mykiss) experience a variety of stressors in their natural environment as well as in aquaculture that can have negative effects on their physiology. The effects of physiological stress and endocrine disruption have been well described in fish. However, there is a scarcity of information on the effects...
Resource Type:: Dissertation
Full Text:: The Effects of Environmental Stressors on Cardiac Gene

Unraveling tissue regeneration using chemical genetics

Creator:: Mathew, Lijoy K.
Abstract:: The emerging field of regenerative medicine is mainly approached by two different aspects. First is the use of stem cell based models to generate a suite of differentiated cells for therapeutic applications and the alternative approach is to utilize the non-mammalian models that have the inherent capacity to regenerate their...
Resource Type:: Dissertation
Full Text:: toxicological, a chemical genetic and a candidate gene approach to define the molecular signaling pathways

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Creator:: Courter, Lauren A.
Abstract:: Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...
Resource Type:: Dissertation
Full Text:: formation, oxidative DNA damage, and changes in gene expression were investigated. In SENCAR mice, both

Factors contributing to the formation of CC-->TT tandem mutations

Creator:: Skinner, Amy M.
Abstract:: The multistage model of carcinogenesis states that an accumulation of mutations in genes that are important for maintaining cellular homeostasis may lead to cancer. A specific type of mutation observed in particular types of cancer is the CC-->TT mutation found in the TP53 gene of patients with basal or squamous...
Resource Type:: Dissertation
Full Text:: mutation found in the TP53 gene of patients with basal or squamous cell carcinoma. Although sunlight (or

Role of Transcriptional Factor COUP-TF-interacting Proteins in Skin Permeability Barrier Development, and in Skin Carcinogenesis, and Role of Lipids in Atopic Dermatitis

Creator:: Li, Shan
Abstract:: Mammalian skin is the largest organ of the body and serves as a barrier to protect the body against chemical, mechanical and pathogenic insults as well as water loss. The epidermis is formed from the primitive ectoderm into a multilayered stratified epithelium, consisting of basal, spinous, granular and outermost cornified...
Resource Type:: Dissertation
Full Text:: dysregulation of cutaneous wound repair. CTIP2 has been described as a tumor suppressor gene in association

Regulation of hepatic pyruvate carboxylase in 2,3,7,8-Tetrachlorodibenzo-p-dioxin treated C57BL/6J mice and their pair-fed controls

Creator:: Roy, Shukla
Resource Type:: Dissertation
Full Text:: previously found in the upstream regulatory region of the mouse PC gene. Presence of consensus sites for

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Creator:: Bajaj, Gaurav
Abstract:: EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...
Resource Type:: Dissertation
Full Text:: , 1995). The NR1 subunit is derived from a single gene and exists in eight different isoforms that are

Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

Creator:: Shenvi, Swapna V.
Abstract:: Glutathione (GSH) is the predominant low molecular weight thiol antioxidant in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...
Resource Type:: Dissertation
Full Text:: Catalytic Subunit Gene: Role of Antioxidant Response Element 3....... 27 2.1 Abstract

ScholarsArchive@OSU

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

The mechanism of interaction of the linker histone with DNA and nucleosomes

The effects of environmental stressors on cardiac gene expression and contractility in rainbow trout (Oncorhynchus mykiss)

Unraveling tissue regeneration using chemical genetics

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Factors contributing to the formation of CC-->TT tandem mutations

Role of Transcriptional Factor COUP-TF-interacting Proteins in Skin Permeability Barrier Development, and in Skin Carcinogenesis, and Role of Lipids in Atopic Dermatitis

Regulation of hepatic pyruvate carboxylase in 2,3,7,8-Tetrachlorodibenzo-p-dioxin treated C57BL/6J mice and their pair-fed controls

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

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