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Filtering by: Creator Giesen, Thomas William Remove constraint Creator: Giesen, Thomas William Committee Member Williams, David Remove constraint Committee Member: Williams, David File Format application/pdf Remove constraint File Format: application/pdf

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Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Creator:

Courter, Lauren A.

Abstract:

Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...

Resource Type:

Dissertation

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Abstract approved: _____________________________________________________________________ William M
Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

Creator:

Shenvi, Swapna V.

Abstract:

Glutathione (GSH) is the predominant low molecular weight thiol antioxidant in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...

Resource Type:

Dissertation

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like to thank my graduate committee members, Drs. William Baird, Balz Frei, Jeffrey Greenwood, and
Unraveling tissue regeneration using chemical genetics

Creator:

Mathew, Lijoy K.

Abstract:

The emerging field of regenerative medicine is mainly approached by two different aspects. First is the use of stem cell based models to generate a suite of differentiated cells for therapeutic applications and the alternative approach is to utilize the non-mammalian models that have the inherent capacity to regenerate their...

Resource Type:

Dissertation
Factors contributing to the formation of CC-->TT tandem mutations

Creator:

Skinner, Amy M.

Abstract:

The multistage model of carcinogenesis states that an accumulation of mutations in genes that are important for maintaining cellular homeostasis may lead to cancer. A specific type of mutation observed in particular types of cancer is the CC-->TT mutation found in the TP53 gene of patients with basal or squamous...

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Dissertation

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Academic Affiliation

Environmental and Molecular Toxicology3

Advisor

Baird, William M.1
Hagen, Tory M.1
Tanguay, Robert L1
Turker, Mitchell S.1

Commencement Year

Commencement Year range begin – Commencement Year range end

Current results range from 2007 to 2008

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Committee Member

Williams, David[remove]4
Baird, William1
Baird, William M.1
Buermeyer, Andrew1
Dashwood, Roderick1
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Creator

Courter, Lauren A.1
Mathew, Lijoy K.1
Shenvi, Swapna V.1
Skinner, Amy M.1

Date

Date range begin – Date range end

Current results range from 2006 to 2007

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Decade

2000-20094

Degree Field

Toxicology3
Molecular and Cellular Biology1

Degree Level

Doctoral4

Degree Name

Doctor of Philosophy (Ph.D.)4

File Format

application/pdf[remove]4

Language

English [eng]4

License

All rights reserved3

Non-Academic Affiliation

Oregon State University. Graduate School4

Peer Reviewed

No4

Resource Type

Dissertation4

Rights Statement

In Copyright4

Subject

Aging -- Genetic aspects1
Aging -- Physiological aspects1
Benzopyrene -- Carcinogenicity1
Carcinogenesis -- Molecular aspects1
Chemical carcinogenesis1
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