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Filtering by: Creator Lee, Chyuan-shen Remove constraint Creator: Lee, Chyuan-shen Committee Member Williams, David Remove constraint Committee Member: Williams, David Non-Academic Affiliation Oregon State University. Graduate School Remove constraint Non-Academic Affiliation: Oregon State University. Graduate School

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Unraveling tissue regeneration using chemical genetics

Creator:

Mathew, Lijoy K.

Abstract:

The emerging field of regenerative medicine is mainly approached by two different aspects. First is the use of stem cell based models to generate a suite of differentiated cells for therapeutic applications and the alternative approach is to utilize the non-mammalian models that have the inherent capacity to regenerate their...

Resource Type:

Dissertation

Full Text:

., 2004; Lee et al., 2005; Mari-Beffa et al., 1996; Nechiporuk and Keating, 2002; Santamaria et al
Prostate cancer prevention with broccoli : from cellular to human studies

Creator:

Clarke, John D.

Abstract:

Prostate cancer is the second leading cause of cancer related death in American men. Epidemiologic studies suggest that cruciferous vegetable intake may lower the risk for many cancers, including prostate and colon. Isothiocyanates (ITC) are phytochemicals derived from cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage that may...

Resource Type:

Dissertation
Interactions of Trichoderma reesei exo-acting cellulases with p-aminophenyl 1-thio-β-D-cellobioside

Creator:

Piyachomkwan, Kuakoon

Abstract:

Cellulolytic enzymes capable of efficiently degrading crystalline cellulose are a complex mixture of endo- (endoglucanases) and exo-acting (cellobiohydrolases) enzymes. One approach to separating these enzymes is affinity chromatography. A new ligand, p-aminophenyl l-thio-β-D-cellobioside (APTC), is introduced for this purpose. The property of APTC in affinity chromatography is demonstrated using Trichoderma...

Resource Type:

Dissertation

Full Text:

(Arai et al, 1989; Vrsanska and Biely, 1992; Shen et al, 1994; Barr et al, 1996). These studies
The mechanism of interaction of the linker histone with DNA and nucleosomes

Creator:

Ellen, Thomas Patrick

Abstract:

This dissertation examines the interaction of the linker histone with DNA and with nucleosomes. The first goal of the project was to characterize the interaction of the linker histone with DNA. Three factors previously reported to influence the linker histone's interaction with DNA were examined: ratio of linker histone to...

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Dissertation

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genes encoding Hi completely knocked out (Shen et al., 1995; Patterton et al., 1998; Hellauer et al
Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

Creator:

Grochowski, Laura L.

Abstract:

Molecular genetic and enzymological techniques have been employed to study secondary metabolite biosynthesis. These investigations have focused on two projects: the cloning and heterologous expression of biosynthetic gene clusters from unculturable marine organisms and the characterization of individual enzymes involved in the biosynthesis of the antifungal agent blasticidin S. The...

Resource Type:

Dissertation
A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Creator:

Myzak, Melinda C.

Abstract:

Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...

Resource Type:

Dissertation
Biotransformation of 2,4,6-trinitrotoluene by ruminal organisms

Creator:

De Lorme, Marthah J. M.

Abstract:

2,4,6-Trinitrotoluene (TNT) has been the common munitions used in the world and is an environmental contaminant that is amendable to reductive transformation reactions. The rumen is an extremely reductive environment containing diverse microbial populations. There are 21 pure culture ruminal bacteria species in culture collection, these were tested for the...

Resource Type:

Dissertation

Full Text:

metabolites of aromatic amino acids, such as tryptophan (Shen et al., 2000). Desulfovibrio strains have
Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Creator:

Courter, Lauren A.

Abstract:

Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...

Resource Type:

Dissertation
Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Creator:

Bajaj, Gaurav

Abstract:

EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...

Resource Type:

Dissertation

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stroke (Choi et al., 1988; Lee et al., 1999). In addition, NMDA type glutamate 3 receptors has
Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

Creator:

Shenvi, Swapna V.

Abstract:

Glutathione (GSH) is the predominant low molecular weight thiol antioxidant in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...

Resource Type:

Dissertation

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Academic Affiliation

Environmental and Molecular Toxicology4
College of Pharmacy3
Biochemistry and Biophysics1
Food Science and Technology1
Microbiology1

Advisor

Ho, Emily2
Anderson, Kim A.1
Baird, William M.1
Craig, A. Morrie1
Dashwood, Roderick H.1
more Advisors »

Commencement Year

Commencement Year range begin – Commencement Year range end

Current results range from 1998 to 2017

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Committee Member

Williams, David[remove]13
Leid, Mark4
Buermeyer, Andrew2
Filtz, Theresa2
Ayres, James1
more Committee Members »

Creator

Bajaj, Gaurav1
Choi, Jin Young, 19641
Clarke, John D.1
Courter, Lauren A.1
de Lorme, Marthah J. M.1
more Creators »

Date

Date range begin – Date range end

Current results range from 1997 to 2016

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Decade

2010-20192
2000-200910
1990-19991

Degree Field

Toxicology4
Molecular and Cellular Biology3
Pharmacy3
Biochemistry and Biophysics1
Food Science and Technology1
more Degree Fields »

Degree Level

Doctoral13

Degree Name

Doctor of Philosophy (Ph.D.)13

File Format

application/pdf3

Language

English [eng]13

License

All rights reserved10

Non-Academic Affiliation

Oregon State University. Graduate School[remove]13

Peer Reviewed

No13

Resource Type

Dissertation13

Rights Statement

In Copyright10
Copyright Not Evaluated3

Subject

Aging -- Genetic aspects1
Aging -- Physiological aspects1
Air -- Pollution -- Mexico, Gulf of1
Air -- Pollution -- Oregon -- Portland1
Air -- Pollution -- Oregon -- Willamette River Valley1
more Subjects »

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