Index Catalog // ScholarsArchive@OSU

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Creator:: Monette, Jeffrey S.
Abstract:: Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...
Resource Type:: Dissertation
Full Text:: S. Monette for the degree of Doctor of Philosophy in Biochemistry and Biophysics presented on

A proteomic approach to 1,2-dichloroethane bioactivation and reaction with redox-active protein disulfide isomerase

Creator:: Kaetzel, Rhonda Sue
Abstract:: Protein disulfide isomerase (PDI), a member of the thioredoxin superfamily, contains two domains with significant sequence homology to the active sites in thioredoxin. PDI facilitates the folding of nascent proteins in the endoplasmic reticulum (ER), binds hormones and Ca²⁺, catalyzes the glutathione dependent reduction of dehydroascorbate, serves as a major...
Resource Type:: Dissertation
Full Text:: showed that the episulfonium ion derived from the glutathione conjugate of 1,2- d ichloroethane, S-(2

Prostate cancer prevention with broccoli : from cellular to human studies

Creator:: Clarke, John D.
Abstract:: Prostate cancer is the second leading cause of cancer related death in American men. Epidemiologic studies suggest that cruciferous vegetable intake may lower the risk for many cancers, including prostate and colon. Isothiocyanates (ITC) are phytochemicals derived from cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage that may...
Resource Type:: Dissertation
Full Text:: broccoli sprouts. Glutathione-S-transferase pi-1 polymorphisms did not affect ITC metabolism

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Creator:: Larsen, Christine A.
Abstract:: Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
Resource Type:: Dissertation
Full Text:: of the MET kinase active site with bound CAT (purple), EC (green), and EGC (blue

Interactions of Trichoderma reesei exo-acting cellulases with p-aminophenyl 1-thio-β-D-cellobioside

Creator:: Piyachomkwan, Kuakoon
Abstract:: Cellulolytic enzymes capable of efficiently degrading crystalline cellulose are a complex mixture of endo- (endoglucanases) and exo-acting (cellobiohydrolases) enzymes. One approach to separating these enzymes is affinity chromatography. A new ligand, p-aminophenyl l-thio-β-D-cellobioside (APTC), is introduced for this purpose. The property of APTC in affinity chromatography is demonstrated using Trichoderma...
Resource Type:: Dissertation
Full Text:: Food Science and Technology cj^ol Dean of Graduate S I understand that my thesis will become part

Studies on isoprenoid biosynthesis in Euglena gracilis

Creator:: Kim, Dojung
Abstract:: This dissertation describes studies of isoprenoid biosynthesis in the phytoflagellate Euglena gracilis. Elucidation of a novel isoprerioid pathway, the 2-Cmethyl-D-erythritol-4-phosphate (MEP) pathway, in addition to the generally known mevalonate (MVA) pathway, led to extensive exploration of the distribution of both pathways in a variety of organisms. To date, photosynthetic eukaryotes...
Resource Type:: Dissertation
Full Text:: prep-TLC preparative TLC q quartet RP Reversed phase s singlet SAM S-Adenosyl methionine t triplet

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Creator:: Courter, Lauren A.
Abstract:: Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...
Resource Type:: Dissertation
Full Text:: growth factor receptor EH epoxide hydrolase EROD ethoxyresorufin O-deethylase GST glutathione S

Regulation of hepatic pyruvate carboxylase in 2,3,7,8-Tetrachlorodibenzo-p-dioxin treated C57BL/6J mice and their pair-fed controls

Creator:: Roy, Shukla
Resource Type:: Dissertation
Full Text:: ) showed that increasing the nuclear protein concentration in the binding reaction causes greater shift(s

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Creator:: Scheri, Richard C.
Abstract:: Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. Even though their use was banned in the United States in 1978, these compounds can still be detected in both humans and wildlife throughout the world. Previous work has shown that the pretreatment of...
Resource Type:: Dissertation
Full Text:: , several values are usually reported and the question of which value(s) to use or some means of

Utilization of lignocellulosic polysaccharides

Creator:: Fenske, John J.
Abstract:: Lignocellulosic biomass represents a vast supply of fermentable carbohydrates and functional aromatic compounds. Conversion of lignocellulosics to ethanol and other useful products would be of widespread economical and environmental benefit. Better understanding of the behavior of different lignicellulosic feedstocks in fermentation protocols as well as catalytic activities involved in lignocellulosic...
Resource Type:: Dissertation
Full Text:: -Glucan-4 glucanohydrolase, EC 3.2.1.4), exoglucanases, or cellobiohydrolases, (1,4-P-D-Glucan

ScholarsArchive@OSU

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

A proteomic approach to 1,2-dichloroethane bioactivation and reaction with redox-active protein disulfide isomerase

Prostate cancer prevention with broccoli : from cellular to human studies

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Interactions of Trichoderma reesei exo-acting cellulases with p-aminophenyl 1-thio-β-D-cellobioside

Studies on isoprenoid biosynthesis in Euglena gracilis

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Regulation of hepatic pyruvate carboxylase in 2,3,7,8-Tetrachlorodibenzo-p-dioxin treated C57BL/6J mice and their pair-fed controls

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Utilization of lignocellulosic polysaccharides

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