Index Catalog // ScholarsArchive@OSU

The effects of environmental stressors on cardiac gene expression and contractility in rainbow trout (Oncorhynchus mykiss)

Creator:: Momoda, Tracey S.
Abstract:: Rainbow trout (Oncorhynchus mykiss) experience a variety of stressors in their natural environment as well as in aquaculture that can have negative effects on their physiology. The effects of physiological stress and endocrine disruption have been well described in fish. However, there is a scarcity of information on the effects...
Resource Type:: Dissertation
Full Text:: determined the effects of a three-hour handling and confinement stress on gene expression in the juvenile

Biotransformation of 2,4,6-trinitrotoluene by ruminal organisms

Creator:: De Lorme, Marthah J. M.
Abstract:: 2,4,6-Trinitrotoluene (TNT) has been the common munitions used in the world and is an environmental contaminant that is amendable to reductive transformation reactions. The rumen is an extremely reductive environment containing diverse microbial populations. There are 21 pure culture ruminal bacteria species in culture collection, these were tested for the...
Resource Type:: Dissertation
Full Text:: Abstract approved: ________________________________________________ A. Morrie Craig 2,4,6

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

Creator:: Grochowski, Laura L.
Abstract:: Molecular genetic and enzymological techniques have been employed to study secondary metabolite biosynthesis. These investigations have focused on two projects: the cloning and heterologous expression of biosynthetic gene clusters from unculturable marine organisms and the characterization of individual enzymes involved in the biosynthesis of the antifungal agent blasticidin S. The...
Resource Type:: Dissertation
Full Text:: biosynthetic gene clusters from complex marine microbe/invertebrate associations. Using this method a mixed

New Applications for Passive Samplers : In-situ Flux and Risk Assessment of Legacy and Emerging Contaminants

Creator:: Tidwell, Lane G.
Abstract:: Passive sampling devices (PSDs) were used to measure air vapor and water dissolved phase concentrations of polycyclic aromatic hydrocarbons (PAHs) and oxygenated PAHs (OPAHs) at two different environmentally contaminated sites. Environmental contaminates like PAHs and OPAHs are present in both the atmospheric and aqueous environmental compartments. It is known that...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ Kim A. Anderson Passive sampling devices (PSDs) were used to measure air vapor and water

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Creator:: Courter, Lauren A.
Abstract:: Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Lauren A. Courter

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Creator:: Larsen, Christine A.
Abstract:: Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
Resource Type:: Dissertation
Full Text:: Doctor of Philosophy dissertation of Christine A AN

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Creator:: Myzak, Melinda C.
Abstract:: Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...
Resource Type:: Dissertation
Full Text:: have an increased susceptibility to cancer (23), which links a specific type of regulation of gene

A proteomic approach to 1,2-dichloroethane bioactivation and reaction with redox-active protein disulfide isomerase

Creator:: Kaetzel, Rhonda Sue
Abstract:: Protein disulfide isomerase (PDI), a member of the thioredoxin superfamily, contains two domains with significant sequence homology to the active sites in thioredoxin. PDI facilitates the folding of nascent proteins in the endoplasmic reticulum (ER), binds hormones and Ca²⁺, catalyzes the glutathione dependent reduction of dehydroascorbate, serves as a major...
Resource Type:: Dissertation
Full Text:: degree of Doctor of Philosophy in Toxicology presented on March 4, 2003. Title: A Proteomic Approach to

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Creator:: Monette, Jeffrey S.
Abstract:: Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...
Resource Type:: Dissertation
Full Text:: April 29, 2011. Title: A Role for Ceramide Accumulation in Age-related Cardiac Mitochondrial

A study of antimutagenicity in yogurt

Creator:: Sudarshan, Nadathur R.
Abstract:: The purpose of this study was to identify antimutagens in yogurt active against the experimental colon carcinogen, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Our initial experiments showed that acetone extracts of yogurt, or milk fermented by various lactic acid bacteria were antimutagenic against MNNG and 3,2'-dimethyl-4-aminobiphenyl (DMAB) in the Ames test (Salmonella typhimurium TA...
Resource Type:: Dissertation
Full Text:: Doctor of Philosophy in Food Science and Technology presented on December 5. 1995. Title: A Study of

ScholarsArchive@OSU

The effects of environmental stressors on cardiac gene expression and contractility in rainbow trout (Oncorhynchus mykiss)

Biotransformation of 2,4,6-trinitrotoluene by ruminal organisms

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

New Applications for Passive Samplers : In-situ Flux and Risk Assessment of Legacy and Emerging Contaminants

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

A proteomic approach to 1,2-dichloroethane bioactivation and reaction with redox-active protein disulfide isomerase

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

A study of antimutagenicity in yogurt

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