Index Catalog // ScholarsArchive@OSU

Biosynthesis and enzymology of conjugated polyenoic fatty acid production in macrophytic marine algae

Creator:: Wise, Mitchell L.
Resource Type:: Dissertation
Full Text:: Abstract approved: William H. Gerwick A novel enzyme, polyenoic fatty acid isomerase, which catalyzes the

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Creator:: Courter, Lauren A.
Abstract:: Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...
Resource Type:: Dissertation
Full Text:: Abstract approved: _____________________________________________________________________ William M

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

Creator:: Grochowski, Laura L.
Abstract:: Molecular genetic and enzymological techniques have been employed to study secondary metabolite biosynthesis. These investigations have focused on two projects: the cloning and heterologous expression of biosynthetic gene clusters from unculturable marine organisms and the characterization of individual enzymes involved in the biosynthesis of the antifungal agent blasticidin S. The...
Resource Type:: Dissertation
Full Text:: .............................................. 16 1.3 Peptide bond formation by a NRPS C-domain ....................... 17 1.4 Reaction catalyzed by

Electron molecule interactions of amino acids and peptides

Creator:: Figard, Benjamin J.
Abstract:: Electron-biomolecule interactions are a biologically relevant field of study because there are several ion fragmentation techniques that have come to the forefront in mass spectrometric analysis that involve the interaction of charged peptides and free electrons. By studying the electron energies that cause fragmentation in neutral amino acids, amino acid...
Resource Type:: Dissertation
Full Text:: the π* orbital at the amide bond leading to formation of z-1 and c type ions

Studies on isoprenoid biosynthesis in Euglena gracilis

Creator:: Kim, Dojung
Abstract:: This dissertation describes studies of isoprenoid biosynthesis in the phytoflagellate Euglena gracilis. Elucidation of a novel isoprerioid pathway, the 2-Cmethyl-D-erythritol-4-phosphate (MEP) pathway, in addition to the generally known mevalonate (MVA) pathway, led to extensive exploration of the distribution of both pathways in a variety of organisms. To date, photosynthetic eukaryotes...
Resource Type:: Dissertation
Full Text:: . William Gerwick, Dr. Victor Hsu, and Dr. David Williams for their support and academic guidance in

The progression of aflatoxin B₁ (AFB₁) hepatocarcinogenesis in rainbow trout (Oncorhynchus mykiss) : I. AFB₁ metabolism and cytotoxicity affecting hepatocarcinogenesis II. Ultrastructure of hepatocellular neoplasms

Creator:: Núñez, Oliva
Resource Type:: Masters Thesis
Full Text:: : implications for risk assessment. Carcinogenesis 9: 2045-2052. Hughes, W.L., Bond, V.P., Brecher, G., Cronkite

Interactions of Trichoderma reesei exo-acting cellulases with p-aminophenyl 1-thio-β-D-cellobioside

Creator:: Piyachomkwan, Kuakoon
Abstract:: Cellulolytic enzymes capable of efficiently degrading crystalline cellulose are a complex mixture of endo- (endoglucanases) and exo-acting (cellobiohydrolases) enzymes. One approach to separating these enzymes is affinity chromatography. A new ligand, p-aminophenyl l-thio-β-D-cellobioside (APTC), is introduced for this purpose. The property of APTC in affinity chromatography is demonstrated using Trichoderma...
Resource Type:: Dissertation
Full Text:: in axial positions. The hydroxyl groups in a glucose unit can form a hydrogen bond between the

Development and application of a new passive sampling device : the lipid-free tube (LFT) sampler

Creator:: Quarles, Lucas W.
Abstract:: Contaminants can exist in a wide range of states in aqueous environments, especially in surface waters. They can be freely dissolved or associated with dissolved or particulate organic matter depending on their chemical and physical characteristics. The freely dissolved fraction represents the most bioavailable fraction to an organism. These freely...
Resource Type:: Masters Thesis
Full Text:: Perez, Julie Layshoc, Kevin Hobbie, Dawn Merrill, Glenn Wilson, Sarah Allan, Norman Forsberg, and

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Creator:: Monette, Jeffrey S.
Abstract:: Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...
Resource Type:: Dissertation

A proteomic approach to 1,2-dichloroethane bioactivation and reaction with redox-active protein disulfide isomerase

Creator:: Kaetzel, Rhonda Sue
Abstract:: Protein disulfide isomerase (PDI), a member of the thioredoxin superfamily, contains two domains with significant sequence homology to the active sites in thioredoxin. PDI facilitates the folding of nascent proteins in the endoplasmic reticulum (ER), binds hormones and Ca²⁺, catalyzes the glutathione dependent reduction of dehydroascorbate, serves as a major...
Resource Type:: Dissertation
Full Text:: . The synthesis of GSH involves formation of the unique amide bond between cysteine and glutamic acid

ScholarsArchive@OSU

Biosynthesis and enzymology of conjugated polyenoic fatty acid production in macrophytic marine algae

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

Electron molecule interactions of amino acids and peptides

Studies on isoprenoid biosynthesis in Euglena gracilis

The progression of aflatoxin B₁ (AFB₁) hepatocarcinogenesis in rainbow trout (Oncorhynchus mykiss) : I. AFB₁ metabolism and cytotoxicity affecting hepatocarcinogenesis II. Ultrastructure of hepatocellular neoplasms

Interactions of Trichoderma reesei exo-acting cellulases with p-aminophenyl 1-thio-β-D-cellobioside

Development and application of a new passive sampling device : the lipid-free tube (LFT) sampler

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

A proteomic approach to 1,2-dichloroethane bioactivation and reaction with redox-active protein disulfide isomerase

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