Index Catalog // ScholarsArchive@OSU

A study of antimutagenicity in yogurt

Creator:: Sudarshan, Nadathur R.
Abstract:: The purpose of this study was to identify antimutagens in yogurt active against the experimental colon carcinogen, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Our initial experiments showed that acetone extracts of yogurt, or milk fermented by various lactic acid bacteria were antimutagenic against MNNG and 3,2'-dimethyl-4-aminobiphenyl (DMAB) in the Ames test (Salmonella typhimurium TA...
Resource Type:: Dissertation
Full Text:: antimutagens in yogurt active against the experimental colon carcinogen, iV-methyl-W-nitro-N-nitrosoguanidine

Development and application of a new passive sampling device : the lipid-free tube (LFT) sampler

Creator:: Quarles, Lucas W.
Abstract:: Contaminants can exist in a wide range of states in aqueous environments, especially in surface waters. They can be freely dissolved or associated with dissolved or particulate organic matter depending on their chemical and physical characteristics. The freely dissolved fraction represents the most bioavailable fraction to an organism. These freely...
Resource Type:: Masters Thesis
Full Text:: chemistry. 2nd ed.; John Wiley & Sons, Inc.: Hoboken, NJ, 2003. 2. Mackay, D.; Shiu, W. Y.; Ma, K.-C.; Lee

Interactions of Trichoderma reesei exo-acting cellulases with p-aminophenyl 1-thio-β-D-cellobioside

Creator:: Piyachomkwan, Kuakoon
Abstract:: Cellulolytic enzymes capable of efficiently degrading crystalline cellulose are a complex mixture of endo- (endoglucanases) and exo-acting (cellobiohydrolases) enzymes. One approach to separating these enzymes is affinity chromatography. A new ligand, p-aminophenyl l-thio-β-D-cellobioside (APTC), is introduced for this purpose. The property of APTC in affinity chromatography is demonstrated using Trichoderma...
Resource Type:: Dissertation
Full Text:: : Interaction of Trichoderma reesei Exo- Acting Cellulases With Immobilized p-Aminophenyl 1-Thio-^-D

The mechanism of interaction of the linker histone with DNA and nucleosomes

Creator:: Ellen, Thomas Patrick
Abstract:: This dissertation examines the interaction of the linker histone with DNA and with nucleosomes. The first goal of the project was to characterize the interaction of the linker histone with DNA. Three factors previously reported to influence the linker histone's interaction with DNA were examined: ratio of linker histone to...
Resource Type:: Dissertation
Full Text:: thanks to my graduate committee members, Dr. Robert Becker, Dr. Lyle Brown, and Dr. David Williams for

Prostate cancer prevention with broccoli : from cellular to human studies

Creator:: Clarke, John D.
Abstract:: Prostate cancer is the second leading cause of cancer related death in American men. Epidemiologic studies suggest that cruciferous vegetable intake may lower the risk for many cancers, including prostate and colon. Isothiocyanates (ITC) are phytochemicals derived from cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage that may...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF John D. Clarke

Biosynthesis and enzymology of conjugated polyenoic fatty acid production in macrophytic marine algae

Creator:: Wise, Mitchell L.
Resource Type:: Dissertation
Full Text:: . The enzyme uses the substrate w-3 and co-6 olefins for alignment in the catalytic site. ICP/MS and

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Creator:: Monette, Jeffrey S.
Abstract:: Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...
Resource Type:: Dissertation
Full Text:: in cardiac mitochondria, young and old F344 rats were pair-fed LA [0.2% (w/w) in the diet] against

Alterations in the permeability of cimetidine by dietary flavonoids using an in vitro transport model, Caco-2 cell

Creator:: Taur, Jan-Shiang
Abstract:: The goal of this dissertation is to investigate the interaction between cimetidine and dietary flavonoids using the Caco-2 cell transport model. It has been shown that flavonoids can change the bioavailability of pharmaceuticals, either by inhibiting metabolizing enzymes or inhibiting the drug efflux transporters. However, the effect of dietary flavonoids...
Resource Type:: Dissertation
Full Text:: Ayres, Dr. Mark Cliristiansen, Dr. David Birkes, and Dr. David Williams, for their precious suggestion

Studies on isoprenoid biosynthesis in Euglena gracilis

Creator:: Kim, Dojung
Abstract:: This dissertation describes studies of isoprenoid biosynthesis in the phytoflagellate Euglena gracilis. Elucidation of a novel isoprerioid pathway, the 2-Cmethyl-D-erythritol-4-phosphate (MEP) pathway, in addition to the generally known mevalonate (MVA) pathway, led to extensive exploration of the distribution of both pathways in a variety of organisms. To date, photosynthetic eukaryotes...
Resource Type:: Dissertation
Full Text:: ) Braithwaite, G. D.; Goodwin, T. W. Biosynthesis of n-carotene from DL-13- Hydroxy-3-methyl-y-[2- 1 4C

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

Creator:: Grochowski, Laura L.
Abstract:: Molecular genetic and enzymological techniques have been employed to study secondary metabolite biosynthesis. These investigations have focused on two projects: the cloning and heterologous expression of biosynthetic gene clusters from unculturable marine organisms and the characterization of individual enzymes involved in the biosynthesis of the antifungal agent blasticidin S. The...
Resource Type:: Dissertation
Full Text:: . Mark Leid, Dr. Theresa Filtz, and Dr. David Wiffiams for their guidance and assistance throughout my

ScholarsArchive@OSU

A study of antimutagenicity in yogurt

Development and application of a new passive sampling device : the lipid-free tube (LFT) sampler

Interactions of Trichoderma reesei exo-acting cellulases with p-aminophenyl 1-thio-β-D-cellobioside

The mechanism of interaction of the linker histone with DNA and nucleosomes

Prostate cancer prevention with broccoli : from cellular to human studies

Biosynthesis and enzymology of conjugated polyenoic fatty acid production in macrophytic marine algae

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Alterations in the permeability of cimetidine by dietary flavonoids using an in vitro transport model, Caco-2 cell

Studies on isoprenoid biosynthesis in Euglena gracilis

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

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