Index Catalog // ScholarsArchive@OSU

Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

Creator:: Shenvi, Swapna V.
Abstract:: Glutathione (GSH) is the predominant low molecular weight thiol antioxidant in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...
Resource Type:: Dissertation
Full Text:: Regulation of Hepatic Glutathione Synthesis: Remediation by R-Alpha-Lipoic Acid Abstract approved

A study of antimutagenicity in yogurt

Creator:: Sudarshan, Nadathur R.
Abstract:: The purpose of this study was to identify antimutagens in yogurt active against the experimental colon carcinogen, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Our initial experiments showed that acetone extracts of yogurt, or milk fermented by various lactic acid bacteria were antimutagenic against MNNG and 3,2'-dimethyl-4-aminobiphenyl (DMAB) in the Ames test (Salmonella typhimurium TA...
Resource Type:: Dissertation
Full Text:: of my thesis committee, Drs. William Sandine, David Williams, Michael Penner, and Floyd Bodyfelt

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Creator:: Courter, Lauren A.
Abstract:: Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...
Resource Type:: Dissertation
Full Text:: Abstract approved: _____________________________________________________________________ William M

Biosynthesis and enzymology of conjugated polyenoic fatty acid production in macrophytic marine algae

Creator:: Wise, Mitchell L.
Resource Type:: Dissertation
Full Text:: Abstract approved: William H. Gerwick A novel enzyme, polyenoic fatty acid isomerase, which catalyzes the

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Creator:: Scheri, Richard C.
Abstract:: Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. Even though their use was banned in the United States in 1978, these compounds can still be detected in both humans and wildlife throughout the world. Previous work has shown that the pretreatment of...
Resource Type:: Dissertation
Full Text:: Abstract approved: __________________________________________________________________ Lawrence R

Influence of wetland landscape structure of shorebirds wintering in an agricultural valley

Creator:: Taft, Oriane Williams
Abstract:: Understanding how wetland birds use habitat is pivotal to developing successful and beneficial conservation strategies. Although it has been an ardent topic in forest research for some time, how species interact with the spatial patterning of habitat across a landscape (i.e., landscape structure) has been more or less neglected in...
Resource Type:: Dissertation
Full Text:: (University of Nevada-Reno), Dennis Peters (NRCS), William Robbins (OSU), Peter Sanzenbacher, Jeff Steiner

Consequences of coumaphos and Varroa destructor on drone honey bee sperm quantity

Creator:: Delaney, Deborah Anne
Abstract:: The number of drones and genetic diversity among drones are essential components to a well mated queen. Varroa destructor preferentially parasitizes drone brood, and is thought to be responsible for the loss of feral populations that once provided additional drones for honey bee mating areas. It is necessary to use...
Resource Type:: Masters Thesis
Full Text:: my graduate committee. I am grateful to Dr. William Winner, former head of the Environmental

A proteomic approach to 1,2-dichloroethane bioactivation and reaction with redox-active protein disulfide isomerase

Creator:: Kaetzel, Rhonda Sue
Abstract:: Protein disulfide isomerase (PDI), a member of the thioredoxin superfamily, contains two domains with significant sequence homology to the active sites in thioredoxin. PDI facilitates the folding of nascent proteins in the endoplasmic reticulum (ER), binds hormones and Ca²⁺, catalyzes the glutathione dependent reduction of dehydroascorbate, serves as a major...
Resource Type:: Dissertation

Unraveling tissue regeneration using chemical genetics

Creator:: Mathew, Lijoy K.
Abstract:: The emerging field of regenerative medicine is mainly approached by two different aspects. First is the use of stem cell based models to generate a suite of differentiated cells for therapeutic applications and the alternative approach is to utilize the non-mammalian models that have the inherent capacity to regenerate their...
Resource Type:: Dissertation
Full Text:: signaling pathways. We hypothesized that, mis-expression of R-Spondin1, a TCDD-induced gene as well as a

Studies on isoprenoid biosynthesis in Euglena gracilis

Creator:: Kim, Dojung
Abstract:: This dissertation describes studies of isoprenoid biosynthesis in the phytoflagellate Euglena gracilis. Elucidation of a novel isoprerioid pathway, the 2-Cmethyl-D-erythritol-4-phosphate (MEP) pathway, in addition to the generally known mevalonate (MVA) pathway, led to extensive exploration of the distribution of both pathways in a variety of organisms. To date, photosynthetic eukaryotes...
Resource Type:: Dissertation
Full Text:: . William Gerwick, Dr. Victor Hsu, and Dr. David Williams for their support and academic guidance in

ScholarsArchive@OSU

Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

A study of antimutagenicity in yogurt

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Biosynthesis and enzymology of conjugated polyenoic fatty acid production in macrophytic marine algae

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Influence of wetland landscape structure of shorebirds wintering in an agricultural valley

Consequences of coumaphos and Varroa destructor on drone honey bee sperm quantity

A proteomic approach to 1,2-dichloroethane bioactivation and reaction with redox-active protein disulfide isomerase

Unraveling tissue regeneration using chemical genetics

Studies on isoprenoid biosynthesis in Euglena gracilis

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